WHO Expert Committee on Biological Standardization (ECBS)
Mission
The WHO Expert Committee on Biological Standardization (ECBS) was established in 1947 to provide detailed recommendations and guidelines for the manufacturing, licensing and control of blood products and related in vitro diagnostic tests, biotechnology products and vaccines along with the establishment of WHO Biological Reference Materials. The ECBS meets on an annual basis and reports directly to the Executive Board, the executive arm of the World Health Assembly.
Members of the Expert Committee are scientists from National Regulatory Agencies, academia, research institutes and public health bodies. The decisions and recommendation of the Committee are based entirely on scientific principles and considerations of public health.
Written guidelines and recommendations submitted to the ECBS are drafted through a consultative process during which WHO brings together experts in the topic from around the world. Reference materials are established through scientific studies involving participation of a large number of laboratories worldwide.
Proceedings of ECBS meetings
The proceedings of the meetings of the ECBS are published in the WHO Technical Report Series (TRS). They provide the information on the establishment, discontinuation and replacement of the WHO Biological Reference Materials as well as on the adoption of Guidelines and Recommendations. The TRS are available electronically as well as publications, and relevant topics can be searched either by the TRS number or by topic, using the navigation bar on the left-hand side of this page.
ECBS 2012
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WHO/BS/2012.2190: Report of a Collaborative Study to assess the suitability of a candidate replacement International Standard for antibody to pandemic H1N1 influenza virus
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WHO/BS/2012.2191: Collaborative Study to Evaluate the Proposed 1st WHO International Standard for Antibodies to Human Papillomavirus Type 18
pdf, 850kb -
WHO/BS/2012.2192: Collaborative Study for the calibration and commutability assessment of the proposed 1st International Standard for Diphtheria Antitoxin Human
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WHO/BS/2012.2193 and QAS/12.501: WHO International Standard for endotoxin
pdf, 1.80Mb -
WHO/BS/2012.2194: Report on a Collaborative Study for proposed 2nd International Standard for Interleukin -2 (IL-2)
pdf, 706kb -
WHO/BS/2012.2195: WHO International Collaborative Study of the proposed 3rd International Standard for Erythropoietin, recombinant, for bioassay
pdf, 406kb -
WHO/BS/2012.2196: WHO International Collaborative Study of the proposed 5th International Standard for human, urinary Follicle-Stimulating Hormones and Human, urinary Luteinizing Hormone, for bioassay
pdf, 704kb -
WHO/BS/2012.2197: Report on a Collaborative Study for proposed 1st WHO reference reagent for human interleukin-29 (IL-29)
pdf, 772kb -
WHO/BS/2012.2198: International Collaborative Study on validation of an in vitro assay system as an alternative to current histamine sensitization test for acellular pertussis vaccines
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WHO/BS/2012.2200: International Collaborative Study to evaluate and establish the 1st WHO Reference Reagent of BCG vaccine of Moreau-RJ sub-strain
pdf, 904kb -
BS/2012.2201: Collaborative Study for the Establishment of the Second International Standard for Neomycin B
pdf, 4.73Mb -
WHO/BS/2012.2202: Collaborative Study for the Establishment of the Third International Standard for Neomycin
pdf, 6.07Mb -
WHO/BS/2012.2203: Requests to initiate new WHO reference material projects for vaccines and related substances; for cytokines, growth factors and endocrinological substances; and for antibiotics
pdf, 385kb -
WHO/BS/2012.2204: An International Collaborative Study to value assign the WHO 2nd IS for Factor VII concentrate (10/252)
pdf, 687kb -
WHO/BS/2012.2205: A Collaborative Study to value assign the who 2ND IS for High Molecular Weight Urokinase (11/184)
pdf, 1.06Mb -
WHO/BS/2012.2206: Evaluation of proposed WHO 1st Reference Reagent for Activated Blood Coagulation Factor XI (FXIa), Human
pdf, 191kb -
WHO/BS/2012.2207: Collaborative Study for Value Assignment of 3rd IS for Low Molecular Weight Heparin
pdf, 552kb -
WHO/BS/2012.2208: Value Assignment to the WHO 2nd IS for Fibrinogen Concentrate (09/242)
pdf, 1.65Mb -
WHO/BS/2012.2209: Report on an International Collaborative Study to establish the 2nd WHO International Subtype Ref. panel for HIV-1 NAT Assays
pdf, 1.16Mb -
WHO/BS/2012.2210: Collaborative Study for Value Assignment of 4th IS for Factor II and X, Concentrate
pdf, 860kb