Biologicals

Biotechnology and related topics

Definitions and scope

Biotechnology describes biological processes that have been engineered. The most common industrial application of biotechnology is the preparation of biological products from genetically engineered bacteria, yeast, fungi, or cells. Cytokines, growth factors, hormones, and other regulatory peptides and proteins are examples. They were originally extracted from tissues and secretions, often of human origin. With the advent of recombinant DNA technology, the preparation of pure, highly concentrated materials became possible, fundamentally changing the manner in which biological materials like these were produced and standardized. Other newly developed examples of biotechnology-derived products are naked DNA vaccines, RNA-based therapeutics, or highly modified viral vectors serving as delivery systems for gene therapy. These complex products bring up new quality concerns - such as the potential consequences of using genetically modified organisms, but they also provide hope of curing life-threatening diseases that are currently untreatable.

Cytokines and growth factors

Growth factors, hormones, and other regulatory peptides and proteins were originally extracted from tissues and secretions, often of human origin. As such, as the purity of such preparations was often low and impurities with traces of other substances common. With the advent of recombinant DNA technology, the preparation of pure, highly concentrated materials became possible, fundamentally changing the manner in which biological materials like these were produced and standardized.

Interferons, human

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Last update:

12 October 2011 09:39 CEST