Vaccines are effective means of reducing the disease burden of infectious diseases in developing countries. To ensure the widest availability of these vaccines in poor countries, approaches are needed with lower production costs and less need of medical personnel to administer the vaccines. A promising avenue is the development of plant-derived vaccines, which can be administered orally or to other mucosal surfaces. Plants are able to produce different classes of proteins of pharmaceutical significance at a high yield, leading to potentially inexpensive products. Oral administration is important as it diminishes the need for needles and syringes which require highly trained immunization staff.