Dengue is a mosquito-borne infection that in recent decades has become a major international public health concern. Dengue is caused by four distinct, closely related, enveloped RNA viruses which are members of the flavivirus group. The dengue viruses, are the most widespread arthropod-borne viruses (arboviruses).

Dengue Vaccines

Dengue fever is a febrile illness that affects infants, young children and adults. Symptoms range from a mild fever, to incapacitating high fever, with severe headache, pain behind the eyes, muscle and joint pain, and rash. More severe forms of the disease are dengue haemorrhagic fever (DHF) which is a potentially lethal complication with fever, abdominal pain, vomiting and bleeding which affects mainly children and dengue shock syndrome (DSS) where a very low blood pressure can cause organ dysfunction.

Dengue vaccine standardization

Written Standards

Guidelines for candidate live attenuated tetravalent dengue virus vaccines were adopted by ECBS 2004.

Reference materials

No WHO reference materials for dengue vaccines are currently available.

Meeting reports

Related information


Last update:

11 February 2015 10:24 CET