Blood products and related biologicals

Blood typing devices

In vitro diagnostic testing for the determination of blood groups is the basis of any blood transfusion and has been performed for decades.

WHO has been involved in this area since 1950s and a number of International Reference Preparations were developed for the control of blood typing reagents.

After a review and update in 1998, the Expert Committee on Biological Standardization (ECBS) decided the replacement of anti-D, complete, anti-D, incomplete as well as anti-A and anti-B would be a priority.

The function of the Reference Preparations is intended to be the definition of the minimum potency of the respective blood typing reagents. They are established for use with tubes and should be suitable for both polyclonal and monoclonal reagents. However, they are not designed to determine specificity.

Reference preparations are established for:

In press
  • Anti-D (anti-Rh0) complete blood-typing serum, mouse monoclonal. 1st International Standard for Minimum Potency of Anti-D Blood Grouping Reagents, Lyophilized. (WHO/BS/04.2000 Rev.1)

Replacement preparations will soon be available for:

  • Anti-A and Anti-B complete blood-typing serum (report to ECBS 2004)



The characteristics of all reference preparations as well as the information regarding establishment can be found in the WHO Reference Material section.

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