Bulletin of the World Health Organization

A randomized, double-blind, placebo-controlled trial of safety and efficacy of combined praziquantel and artemether treatment for acute schistosomiasis japonica in China

Xun-Ya Hou, Donald P McManus, Darren J Gray, Julie Balen, Xin-Song Luo, Yong-Kang He, Magda Ellis, Gail M Williams, Yue-Sheng Li

Volume 86, Number 10, October 2008, 788-795

Table 2. Demographic/clinical data and water exposure of subjects in various treatment groups at baseline

Characteristics Group A(n = 53) Group B(n = 56) Group C(n = 45) Group D(n = 51) P-value
Mean age in years (SD) 24.9 (15.1) 23.6 (14.0) 19.4 (10.4) 20.7 (12.3) 0.147
Male/female 49/4 51/5 43/2 49/2 0.674
Mean weight in kg (SD) 48.6 (15.6) 47.1 (14.8) 45.0 (15.8) 43.9 (16.1) 0.420
Occupation
Farmer 9 (17.0%) 10 (17.9%) 1 (2.2%) 8 (15.7%) 0.067
Fisherman 14 (26.4%) 9 (16.1%) 3 (6.7%) 3 (5.9%) 0.009
Businessman 6 (11.3%) 4 (7.1%) 13 (28.9%) 8 (15.7%) 0.123
Student 24 (45.3%) 33 (58.9%) 28 (62.2%) 32 (62.7%) 0.630
Water exposure in days
Mean (SD) 15.0 (17.9) 8.7 (15.9) 12.6 (17.9) 10.2 (16.4) 0.097
Median (range) 2 (1–49) 1 (1–61) 3 (1–60) 1 (1–56) 0.078
Mean number of days of fever before hospitalization (range) 9 (1–46) 9 (1–38) 10 (2–30) 9 (2–30) 0.711
Mean temperature in °C on admission (SD) 38.3 (1.0) 38.5 (0.8) 38.7 (1.2) 38.2 (1.1) 0.108
Clinical symptoms
Fatigue 48 (90.6%) 45 (80.4%) 44 (97.8%) 43 (84.3%) 0.450
Loss of appetite 33 (66.0%) 36 (67.9%) 34 (82.2%) 33 (68.6%) 0.288
Cough 23 (43.4%) 25 (44.6%) 28 (62.2%) 31 (60.8%) 0.100
Dizziness 27 (50.9%) 26 (46.4%) 28 (62.2%) 22 (43.1%) 0.267
Diarrhoea 19 (35.8%) 29 (51.8%) 17 (37.8%) 17 (33.3%) 0.199
Abdominal distension 12 (22.6%) 16 (28.6%) 15 (33.3%) 11 (21.6%) 0.522
Abdominal pain 6 (11.3%) 12 (21.4%) 9 (20.0%) 10 (19.6%) 0.521
Hepatomegaly 23 (43.4%) 27 (48.2%) 17 (37.7%) 18 (35.3%) 0.535
Splenomegaly 6 (11.3%) 11 (19.6%) 6 (13.3%) 5 (9.8%) 0.459

SD, standard deviation.

[an error occurred while processing this directive]