Bulletin of the World Health Organization

A randomized, double-blind, placebo-controlled trial of safety and efficacy of combined praziquantel and artemether treatment for acute schistosomiasis japonica in China

Xun-Ya Hou, Donald P McManus, Darren J Gray, Julie Balen, Xin-Song Luo, Yong-Kang He, Magda Ellis, Gail M Williams, Yue-Sheng Li

Volume 86, Number 10, October 2008, 788-795

Table 3. Infection intensity, treatment efficacy and blood biochemistry of subjects in various treatment groups

Parametersa Group A(n = 51) Group B(n = 55) Group C(n = 44) Group D(n = 46) P-value
Cases positive: baseline 51 55 44 46
Mean epg baseline (95% CI) 54.6 81.7 51.5 50.6 0.265
(35.7–83.5) (58.4–114.3) (33.1–80) (34.2–74.8)
Cases positive: follow-up 1 2 1 2
Treatment efficacy in % 98 96.4 97.7 95.7 0.947
Mean ALT0, μ/l (SD) (n = 205) 54.3 (41.0) 66.2 (50.2) 48.9 (20.5) 57.9 (41.1) 0.531
Mean ALT10, μ/l (SD) 69.6 (55.2) 77.4 (44.2) 54.7 (31.0) 66.9 (65.5) 0.527
Mean ALT20, μ/l (SD) 53.7 (35.6) 49.2 (15.8) 35.7 (11.8) 34.6 (21.4) 0.358
Mean BUN0, mmol/L (SD) 3.5 (1.2) 3.6 (0.9) 3.0 (1.1) 3.1 (1.1) 0.852
Mean BUN20, mmol/L (SD) 3.4 (1.6) 3.4 (1.6) 3.4 (1.2) 3.1 (1.0) 0.776
Mean blood creatinine0, mmol/L (SD) 75.2 (25.2) 70.5 (15.6) 77.7 (18.5) 80.4 (21.9) 0.729
Mean blood creatinine20, µmol/L (SD) 72.6 (21.2) 73.7 (19.1) 78.5 (13.5) 74.5 (18.5) 0.458
Mean haemoglobin0, g/dl (SD) 119.9 (18.5) 120.1 (11.9) 126.3 (13.7) 121.4 (13.1) 0.794
Mean haemoglobin20, g/dl, (SD) 129.0 (15.4) 119.3 (16.1) 123.6 (16.8) 122.1 (14.7) 0.625
Mean eosinophils0, % (SD) 33.8 (33.5) 31.2 (21.9) 25.5 (15.2) 36.0 (27.9) 0.595
Mean eosinophils20, % (SD) 33.3 (22.4) 31.7 (20.5) 24.0 (12.6) 32.9 (11.9) 0.434

ALT, alanine aminotransferase; BUN, blood urea nitrogen; CI, confidence interval; epg, eggs per gram; SD, standard deviation.a Numbers in subscript indicate days post-treatment with artemether.

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