Bulletin of the World Health Organization

A cohort study to assess the new WHO Japanese encephalitis surveillance standards

Tom Solomon, Thi Thu Thao, Penny Lewthwaite, Mong How Ooi, Rachel Kneen, Nguyen Minh Dung, Nicholas White

Volume 86, Number 3, March 2008, 178-186

Table 2. Effect of different case definitions on the sensitivity, specificity and positive and negative predictive values for JEV infection in children

Case definition JE positive (N = 54) JE negative (N = 62) JE unknown (N = 33) All (N = 149) Sensitivity (%)a Specificity (%)a PPV (%) NPV (%)
AES 35 38 23 96 65 (56–73) 39 (30–48) 48 56
AES, acute paralysis or both 47 46 26 119 87 (81–93) 26 (18–34) 51 70
AES, meningism or both 48 48 29 125 89 (83–95) 23 (15–30) 50 70
AES at any time during hospitalization 41 44 25 110 76 (68–84) 29 (21–37) 48 58

AES, acute encephalitis syndrome (defined as acute febrile illness and change in mental status or new onset seizures); JEV, Japanese encephalitis virus; NPV, negative predictive value; PPV, positive predictive value.a 95% confidence intervals are presented in parentheses.

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