A cohort study to assess the new WHO Japanese encephalitis surveillance standards
Tom Solomon, Thi Thu Thao, Penny Lewthwaite, Mong How Ooi, Rachel Kneen, Nguyen Minh Dung, Nicholas White
Volume 86, Number 3, March 2008, 178-186
Table 2. Effect of different case definitions on the sensitivity, specificity and positive and negative predictive values for JEV infection in children
| Case definition | JE positive (N = 54) | JE negative (N = 62) | JE unknown (N = 33) | All (N = 149) | Sensitivity (%)a | Specificity (%)a | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|---|---|
| AES | 35 | 38 | 23 | 96 | 65 (56–73) | 39 (30–48) | 48 | 56 |
| AES, acute paralysis or both | 47 | 46 | 26 | 119 | 87 (81–93) | 26 (18–34) | 51 | 70 |
| AES, meningism or both | 48 | 48 | 29 | 125 | 89 (83–95) | 23 (15–30) | 50 | 70 |
| AES at any time during hospitalization | 41 | 44 | 25 | 110 | 76 (68–84) | 29 (21–37) | 48 | 58 |
AES, acute encephalitis syndrome (defined as acute febrile illness and change in mental status or new onset seizures); JEV, Japanese encephalitis virus; NPV, negative predictive value; PPV, positive predictive value.a 95% confidence intervals are presented in parentheses.