Safety profile of pneumococcal conjugate vaccines: systematic review of pre- and post-licensure data
Frank DeStefano, Dina Pfeifer, Hanna Nohynek
Volume 86, Number 5, May 2008, 373-380
Table 3. Reactogenicity of any severity for PCV7 according to age at dose administration: nonrandomized studies in healthy children under 3 years of age
| Reactogenicity | Age at dose administration (months) | Study |
|||
|---|---|---|---|---|---|
| Fernández et al. |
Käyhty et al. |
Shao et al. |
|||
| PCV7 (n) | – | 115 | 101 | 60 | |
| Comparison | – | none | DTaP-IPV/Hib | none | |
| Redness (%) | 2 | – | 1.0 (3 months) | 17 | |
| 4 | – | 5.1 (5 months) | 22 | ||
| 6 | – | – | 28 | ||
| 12–15 | – | 18.2 | – | ||
| 17–19 | – | – | 50 | ||
| 24–36 | 40.0 | – | |||
| Swelling (%) | 2 | – | 5.9 (3 months) | 17 | |
| 4 | – | 19.2 (5 months) | 18 | ||
| 6 | – | – | 25 | ||
| 12–15 | – | 21.2 | |||
| 17–19 | – | – | 47 | ||
| 24–36 | 32.2 | – | – | ||
| Fever (%) | 2 | – | 38 (3 months) | 35 | |
| 4 | – | 54 (5 months) | 48 | ||
| 6 | – | – | 32 | ||
| 12–15 | – | 62 | – | ||
| 17–19 | – | – | 50 | ||
| 24–36 | 7.0 | – | – | ||
DTaP-IPV/Hib, diphtheria, tetanus, pertussis (acellular antigens), inactivated polio vaccine and Haemophilus influenzae type b; PCV7, 7-valent pneumococcal polysaccharide-protein conjugate vaccine.