Anthropometric and immunological success of antiretroviral therapy and prediction of virological success in west African adults
Eugène Messou, Delphine Gabillard, Raoul Moh, André Inwoley, Souleymane Sorho, Serge Eholié, François Rouet, Catherine Seyler, Christine Danel, Xavier Anglaret
Volume 86, Number 6, June 2008, 435-442
Table 3. Sensitivity, specificity and predictive values of a loss in BMI, a loss in CD4 cells or both, for predicting virological failure at 6 months
| Loss in BMI and/or CD4 | No. of patients(N)a | No. with virological failure(n)b | Se(%) | Sp(%) | PPV(%) | NPV(%) |
|---|---|---|---|---|---|---|
| < –4 kg/m² | 2 | 0 | 0 | 99 | 0 | 84 |
| < –3 kg/m² | 6 | 1 | 1 | 99 | 17 | 84 |
| < –2 kg/m² | 23 | 4 | 4 | 96 | 17 | 84 |
| < –1 kg/m² | 61 | 8 | 8 | 90 | 13 | 84 |
| < 0 kg/m² | 140 | 23 | 23 | 78 | 16 | 84 |
| < –150/μl | 2 | 0 | 0 | 99 | 0 | 84 |
| < –100/μl | 6 | 1 | 1 | 99 | 17 | 84 |
| < –50/μl | 29 | 6 | 6 | 96 | 21 | 84 |
| < 0/μl | 67 | 18 | 18 | 90 | 27 | 85 |
| < –1 kg/m² and < –50/μl | 8 | 1 | 1 | 99 | 13 | 84 |
| < 0 kg/m² and < 0/μl | 25 | 9 | 9 | 97 | 36 | 85 |
BMI, body mass index; CD4, CD4+ T-cell count; NPV, negative predictive value; PPV, positive predictive value; Se, sensitivity; Sp, specificity.a No. of patients in whom the gain in BMI and/or the gain in CD4 is higher than the corresponding threshold at 6 months.b No. of patients with undetectable viral load at 6 months.