Bulletin of the World Health Organization

Ivermectin versus benzyl benzoate applied once or twice to treat human scabies in Dakar, Senegal: a randomized controlled trial

Fatimata Ly, Eric Caumes, Cheick Ahmet Tidiane Ndaw, Bassirou Ndiaye & Antoine Mahé

Volume 87, Number 6, June 2009, 424-430

Table 4. Results of various therapeutic trials comparing oral IV with topical treatment for common scabies

Ivermectin	Comparison drug	n	Cure rate (%)(IV vs comparison drug)	P-value	Lost to follow-upNo. (%)	Reference
100 µg/kg once	10% BB for 12 hours	44	70 vs 48 at 1 month	0.08	0 (0)	¹²
200 µg/kg once or twice^a	5% permethrin in single overnight application	85	70 vs 98 at 2 weeks 95 vs 100 at 4 weeks	0.0004	0 (0)	¹³
200 µg/kg once or twice^a	5% permethrin in single overnight application	85	70 vs 98 at 2 weeks 95 vs 100 at 4 weeks	0.22	0 (0)	¹³
150–200 µg/kg once or twice^a	1% lindane	53	74 vs 54 at 2 weeks 95 vs 96 at 4 weeks	0.19	10 (19)	¹⁴
150–200 µg/kg once or twice^a	1% lindane	53	74 vs 54 at 2 weeks 95 vs 96 at 4 weeks	0.99	10 (19)	¹⁴
200 µg/kg once	1% lindane	200	82 vs 44 at 4 weeks	< 10^–5	50 (25)	¹⁵
200 µg/kg once	10% BB	110	56 vs 51 at 3 weeks	0.69	30 (27)	¹⁶
200 µg/kg once	25% BB	58	93 vs 48 at 30 days	0.0002	Unknown	¹⁷
200 µg/kg once or twice^a	25% BB daily for 3 consecutive days	210	79 vs 59 at 2 weeks 95 vs 86 at 4 weeks	0.003	10 (4)	¹⁸
200 µg/kg once or twice^a	25% BB daily for 3 consecutive days	210	79 vs 59 at 2 weeks 95 vs 86 at 4 weeks	0.04	10 (4)	¹⁸

BB, benzyl benzoate; IV, ivermectin.
^a Two weeks after the first dose.