Disseminated bacille Calmette–Guérin disease in HIV-infected South African infants
AC Hesseling, LF Johnson, H Jaspan, MF Cotton, A Whitelaw, HS Schaaf, PEM Fine, BS Eley, BJ Marais, J Nuttall, N Beyers & P Godfrey-Faussett
Volume 87, Number 7, July 2009, 505-511
Table 1. Estimated incidence of disseminated BCG disease in HIV-infected infants (aged ≤ 1 year) vaccinated at birth with BCG, Western Cape Province, South Africa
| Year |
|||
|---|---|---|---|
| 2004 | 2005 | 2006 | |
| No. of cases of disseminated BCG disease in HIV-infected infants ≤ 1 year of age | 12 | 12 | 8 |
| Estimated total no. of infants ≤ 1 year of age | 98 236 | 98 339 | 98 137 |
| Provincial maternal HIV prevalence (% and 95% CI) | 15.4 (12.5–18.2) | 15.7 (11.3–20.1) | 15.2 (11.6–18.7) |
| Reported vertical HIV transmission rate (%) | 10.4 | 6.1 | 5.4 |
| Estimated total no. of HIV-infected infants | 1573 | 942 | 806 |
| Estimated incidence of disseminated BCG diseasea, assuming 98–99% BCG vaccination coverage (no. and 95% CI) | 778 (361–1319) | 1300 (587–2290) | 1013 (377–1895) |
BCG, bacille Calmette-Guérin; CI, confidence interval.
a Per 100 000 HIV-infected vaccinated infants. The pooled estimate for the incidence of disseminated BCG disease over the entire study period was 992 per 100 000 HIV-infected, BCG-vaccinated infants (95% CI: 567–1495).