Misoprostol to prevent and treat postpartum haemorrhage: a systematic review and meta-analysis of maternal deaths and dose-related effects
G Justus Hofmeyr, A Metin Gülmezoglu, Natalia Novikova, Verena Linder, Sandra Ferreira & Gilda Piaggio
Volume 87, Number 9, September 2009, 666-677
Table 3. Meta-analysis of direct comparisons and adjusted indirect comparisons of misoprostol, another uterotonic or placebo for risk of PPH
| PPH (≥ 1000 ml of blood) | RR | 95% CI |
|---|---|---|
| Direct comparison, M, 600 µg vs 400 µg | 0.841 | 0.501–1.411 |
| Indirect adjusted comparison, M, 600 µg or 400 µg, vs P | 1.420 | 0.790–2.555 |
| Indirect adjusted comparison, M, 600 µg or 400 µg, vs U | 0.931 | 0.599–1.446 |
| All | 1.023 | 0.707–1.481 |
CI, confidence interval; M, misoprostol; P, placebo; PPH, postpartum haemorrhage; RR, relative risk; U, uterotonic besides misoprostol.