Misoprostol to prevent and treat postpartum haemorrhage: a systematic review and meta-analysis of maternal deaths and dose-related effects
G Justus Hofmeyr, A Metin Gülmezoglu, Natalia Novikova, Verena Linder, Sandra Ferreira & Gilda Piaggio
Volume 87, Number 9, September 2009, 666-677
Table 4. Meta-analysis of direct comparisons and adjusted indirect comparisons of misoprostol, another uterotonic, or placebo for risk of pyrexia
| Pyrexia (body temperature ≥ 38 °C) | RR | 95% CI |
|---|---|---|
| Direct comparison, M, 600 µg vs 400 µg | 2.059 | 1.399–3.031 |
| Indirect adjusted comparison, M, 600 µg or 400 µg, vs P | 1.944 | 0.676–5.596 |
| Indirect adjusted comparison, 600 µg or 400 µg, vs U | 2.656 | 1.878–3.758 |
| All | 2.532 | 1.779–3.604 |
CI, confidence interval; M, misoprostol; P, placebo; RR, relative risk; U, uterotonic besides misoprostol.