Bulletin of the World Health Organization

Structured approaches for the screening and diagnosis of childhood tuberculosis in a high prevalence region of South Africa

Mark Hatherill, Monique Hanslo, Tony Hawkridge, Francesca Little, Lesley Workman, Hassan Mahomed, Michele Tameris, Sizulu Moyo, Hennie Geldenhuys, Willem Hanekom, Lawrence Geiter & Gregory Hussey

Volume 88, Number 4, April 2010, 312-320

Table 3. Differences in case frequencya yielded by nine structured approaches for the diagnosis of tuberculosis, South Africa, 2001–2006

System MASA Migliori SATVI Osborne Stoltz–Donald Kibel Fourie WHO–Harries Stegen–Toledo No. (%) diagnosed with tuberculosis
MASA 34.8 (32.3–37.3) 44.2 (41.7–47.0) 82.3 (80.3–84.3) 22.0 (19.8–24.2) 63.1 (60.5–65.7) 23.5 (21.0–26.2) 3.1 (1.3–5.1) 46.5 (43.9–49.2) 99 (6.9)
Migliori P < 0.0001 9.4 (6.7–12.2) 47.5 (44.8–50.3) 12.8 (10.0–15.6) 28.3 (25.4–31.2) 11.3 (8.3–14.1) 31.7 (28.9–34.3) 11.7 (9.8–13.7) 602 (41.7)
SATVI P < 0.0001 P < 0.0001 38.1 (35.3–40.8) 22.2 (20.1–24.5) 18.9 (16.0–21.7) 20.7 (17.5–23.9) 41.1 (38.3–43.9) 2.3 (−0.3–4.9) 739 (51.1)
Osborne P < 0.0001 P < 0.0001 P < 0.0001 60.3 (57.7–63.0) 19.2 (16.9–21.6) 58.8 (56.0–61.5) 79.2 (76.9–81.4) 35.8 (33.1–38.4) 1289 (89.2)
Stoltz–Donald P < 0.0001 P < 0.0001 P < 0.0001 P < 0.0001 41.1 (38.2–44.0) 1.5 (−1.6–4.8) 18.9 (16.1–21.6) 24.5 (22.0–27.2) 417 (28.9)
Kibel P < 0.0001 P < 0.0001 P < 0.0001 P < 0.0001 P < 0.0001 39.6 (36.5–42.5) 60.0 (57.3–62.6) 16.6 (13.8–19.3) 1011 (70.0)
Fourie P < 0.0001 P < 0.0001 P < 0.0001 P < 0.0001 P = 0.344 P < 0.0001 20.4 (17.9–22.9) 23.0 (19.8–26.1) 440 (30.4)
WHO–Harries P = 0.0009 P < 0.0001 P < 0.0001 P < 0.0001 P < 0.0001 P < 0.0001 P < 0.0001 43.4 (40.6–46.2) 145 (10.0)
Stegen–Toledo P < 0.0001 P < 0.0001 P = 0.083 P < 0.0001 P < 0.0001 P < 0.0001 P < 0.0001 P < 0.0001 772 (53.4)
No. (%) diagnosed with tuberculosis 99 (6.9) 602 (41.7) 739 (51.1) 1289 (89.2) 417 (28.9) 1011 (70.0) 440 (30.4) 145 (10.0) 772 (53.4) 1445 (100)

MASA, Medical Association of South Africa; SATVI, South African Tuberculosis Vaccine Initiative; WHO, World Health Organization.
a Absolute differences in proportion (denominator =1445) and corresponding 95% CIs are above diagonal spaces; McNemar’s test P-values for differences in proportion are below diagonal spaces.

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