Scale-up of a decentralized HIV treatment programme in rural KwaZulu-Natal, South Africa: does rapid expansion affect patient outcomes?
Portia C Mutevedzi, Richard J Lessells, Tom Heller, Till Bärnighausen, Graham S Cooke & Marie-Louise Newell
Volume 88, Number 8, August 2010, 593-600
Table 2. Outcomes from a 3-year cohort of 3010 patients at 12 months following initiation of antiretroviral therapy in a decentralized HIV treatment programme in rural KwaZulu-Natal, South Africa, 2004–2007
| Outcome | Oct 04–Mar 05 |
Apr 05–Sep 05 |
Oct 05–Mar 06 |
Apr 06–Sep 06 |
Oct 06–Mar 07 |
Apr 07–Sep 07 |
Total |
P | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % | 95% CI | % | 95% CI | % | 95% CI | % | 95% CI | % | 95% CI | % | 95% CI | % | 95% CI | ||||||||
| On treatment | 79.1 | 72.3–85.9 | 90.9 | 87.2–94.5 | 85.6 | 82.6–88.7 | 86.8 | 83.9–89.7 | 83.3 | 80.4–86.2 | 80.9 | 78.4–83.4 | 84.0 | 82.6–5.3 | 0.623 | ||||||
| Death | 19.4 | 12.8–26.0 | 7.9 | 4.5–11.3 | 10.4 | 7.7–13.1 | 8.0 | 5.7–10.3 | 11.5 | 9.0–13.9 | 12.0 | 9.9–14.1 | 10.9 | 9.8–12.0 | 0.015 | ||||||
| Lost to follow-up | 0.7 | 0–2.0 | 0.8 | 0–2.0 | 3.6 | 2.0–5.2 | 4.2 | 2.5–5.9 | 4.0 | 2.5–5.5 | 4.5 | 3.2–5.8 | 3.7 | 3.0–4.4 | 0.034 | ||||||
| Transferred out | 0.7 | 0–2.1 | 0.4 | 0–1.2 | 0.4 | 0–1.0 | 1.0 | 0.1–1.8 | 1.2 | 0.4–2.1 | 2.6 | 1.6–3.6 | 1.4 | 1.0–1.8 | 0.171 | ||||||
| Detectable viral load | 41.4 | 28.5–54.2 | 41.5 | 32.1–50.9 | 28.8 | 23.4–34.1 | 23.0 | 18.6–27.3 | 16.5 | 13.1–19.8 | 21.5 | 18.4–24.5 | 23.3 | 21.4–25.1 | 0.001 | ||||||
CI, confidence interval; HIV, human immunodeficiency virus.