Bulletin of the World Health Organization

Global burden of chronic pulmonary aspergillosis as a sequel to pulmonary tuberculosis

David W Denning, Alex Pleuvry & Donald C Cole

Volume 89, Number 12, December 2011, 864-872

Table 4. Estimated global burden of chronic pulmonary aspergillosis (CPA) after pulmonary tuberculosis (TB), by World Health Organization (WHO) region, for different rates of annual attrition (10–25%) and CPA frequency estimatesa

CPA frequency
Global
Europe
Africa
Eastern Mediterranean
Americas
Western Pacific
South-East Asia
TB cavity No TB cavity 10% 15% 25% 10% 15% 25% 10% 15% 25% 10% 15% 25% 10% 15% 25% 10% 15% 25% 10% 15% 25%
30% 4% 2 088 604 1 786 412 1 296 646 68 111 58 256 42 284 551 639 471 825 342 469 115 395 98 699 71 639 70 584 60 371 43 820 469 154 401 274 291 260 813 721 695 987 505 174
22% 4% 1 713 570 1 465 640 1 063 817 58 927 56 401 36 583 451 754 386 392 280 458 94 500 80 828 58 668 57 803 49 440 35 885 384 204 328 615 238 522 666 381 569 965 413 702
22% 2% 1 372 457 1 173 881 852 048 42 091 36 001 26 131 363 219 310 667 225 494 75 980 64 987 47 170 46 475 39 751 28 852 308 908 264 213 191 776 535 783 458 263 332 625
22% 1% 1 201 900 1 028 002 746 163 33 673 28 801 20 905 318 952 272 804 198 012 66 720 57 067 41 421 40 811 34 906 25 336 271 260 232 012 168 403 470 485 402 412 292 086
10% 1% 639 349 546 844 396 920 19 898 17 019 12 353 169 124 144 654 104 995 35 378 30 260 21 964 21 640 18 509 13 434 143 835 123 024 89 296 249 474 213 379 154 878

a Estimated frequency was 10–30% in patients with cavities and 1–4% in patients without cavities after completion of anti-tuberculous therapy.