Presumptive diagnosis of severe HIV infection to determine the need for antiretroviral therapy in children less than 18 months of age
Nicolas Grundmann, Peter Iliff, Jeff Stringer & Catherine Wilfert
Volume 89, Number 7, July 2011, 513-520
Table 3. Test characteristics of three screening algorithms for presumptively diagnosing severe human immunodeficiency virus (HIV) disease in infants, by infant age at testing
| Characteristic | MCC only | MCC + RAT | MCC + RAT + CD4 count |
|---|---|---|---|
| 6 weeks | |||
| SE | 19.5 | 19.5 | 71.2 |
| SP | 94.0 | 94.1 | 93.9 |
| PPV | 27.0 | 30.7 | 60.9 |
| NPV | 91.4 | 89.7 | 96.1 |
| 6 months | |||
| SE | 48.3 | 48.3 | 71.0 |
| SP | 84.4 | 92.2 | 92.2 |
| PPV | 34.5 | 51.1 | 60.6 |
| NPV | 90.6 | 91.3 | 94.9 |
| 12 months | |||
| SE | 67.9 | 67.8 | 79.8 |
| SP | 90.4 | 99.5 | 99.5 |
| PPV | 61.6 | 96.9 | 97.3 |
| NPV | 92.6 | 93.2 | 95.6 |
CD4, CD4+ T lymphocyte; MCC, modified clinical criteria; NPV, negative predictive value; PPV, positive predictive value; RAT, rapid antibody test; SE, sensitivity; SP, specificity.