Electronic monitoring of treatment adherence and validation of alternative adherence measures in tuberculosis patients: a pilot study
Jossy van den Boogaard, Ramsey A Lyimo, Martin J Boeree, Gibson S Kibiki & Rob E Aarnoutse
Volume 89, Number 9, September 2011, 632-639
Table 3. Sensitivity, specificity, positive and negative predictive values, and accuracy of individual treatment adherence measures, alone and in combination, in a study of adherence to tuberculosis treatment, United Republic of Tanzania, 2010
|< 100%||< 95%||< 100%||< 95%||< 100%||< 95%||< 100%||< 95%||< 100%||< 95%|
|INH urine test||33||43||40||60||60||20||18||82||35||57|
|Urine colour test||74||86||20||27||71||21||22||89||59||38|
|Refill visits + pill counts||41||29||60||57||73||13||27||77||46||51|
|Refill visits + pill counts + ACTG questionnaire||79||100||0||20||68||23||0||100||57||35|
|Refill visits + pill counts + urine colour test||78||86||20||23||72||21||25||88||62||35|
|Refill visits + pill counts + BMQ||69||71||50||38||78||22||39||85||64||44|
|Refill visits + pill counts + INH urine test||63||71||30||37||71||21||23||85||54||43|
|Refill visits + pill counts + Morisky scale||41||29||60||57||73||13||27||77||46||51|
ACTG, AIDS Clinical Trials Group; BMQ, Brief Medication Questionnaire; INH, isoniazid; MEMS, Medication Event Monitoring System; NPV, negative predictive value; PPV, positive predictive value.
a Sensitivity: the proportion of non-adherent individuals correctly identified as non-adherent by the measure.
b Specificity: the proportion of adherent individuals correctly identified as adherent by the measure.
c Positive predictive value: the proportion of non-adherent individuals according to the measure who were non-adherent according to MEMS.
d Negative predictive value: the proportion of adherent individuals according to the measure who were adherent according to MEMS.
e Accuracy: the proportion of individuals correctly identified as either adherent or non-adherent by the measure.
f Non-adherence defined as an adherence rate of < 100% (27 patients) or < 95% (7 patients) as assessed by MEMS.