Bulletin of the World Health Organization

The impact of new tuberculosis diagnostics on transmission: why context matters

Hsien-Ho Lin, David Dowdy, Christopher Dye, Megan Murray & Ted Cohen

Volume 90, Number 10, October 2012, 739-747A

Table 2. Modes and value ranges for operational parameters investigated in the one-way sensitivity analysis in a study of the impact of new tuberculosis diagnostics on transmission

Parameter Lowa Mode Higha
Patient delay, HIV-negative (months) 1.7 2.0 15.6
Patient delay, HIV-positive (months) 1.3 2.0 6.3
Access to care (%) 63 83 99
Diagnostic default (%) 1 5 18
Sensitivity of existing diagnostic strategies for smear-negative cases (%) 13 31 71
Initial (i.e. post-diagnostic) default (%) 1 23 29
Treatment success rate (%) 54 70 96

HIV, human immunodeficiency virus.

a The low and high values correspond to the 5th and 95th percentile values in the posterior distribution.

Note: The values were obtained from posterior distributions after the Bayesian melding procedure that calibrated the input parameters to the tuberculosis rates observed in the United Republic of Tanzania.