Timing of antiretroviral therapy in Cambodian hospital after diagnosis of tuberculosis: impact of revised WHO guidelines
Kimcheng Choun, Reaksmey Pe, Sopheak Thai, Natalie Lorent, Lutgarde Lynen & Johan van Griensven
Volume 91, Number 3, March 2013, 195-206
Table 2. Time (weeks) between the diagnosis of tuberculosis and initiation of antiretroviral therapy (ART) pre- and post-implementation of the 2010 WHO ART guidelines, Cambodia, December 2008 to November 2011
| Parameter | Median in weeks from tuberculosis diagnosis to ART (IQR) |
||
|---|---|---|---|
| Before (n = 210) | After (n = 152) | P | |
| CD4+ cell count (cells/µL) at start of antituberculosis treatment | |||
| All | 6.3 (4.1–10.0) | 3.1 (2.4–5.1) | < 0.001 |
| > 50 | 7.0 (5.3–11.3) | 3.6 (2.9–5.3) | < 0.001 |
| ≤ 50 | 5.8 (3.7–9.0) | 3.0 (2.1–4.4) | < 0.001 |
| Sex | |||
| Female | 6.3 (3.9–10.0) | 4.0 (2.6–5.1) | < 0.001 |
| Male | 5.8 (3.4–9.6) | 2.8 (2.0–4.3) | < 0.001 |
| Age (years) | |||
| ≤ 35 | 3.1 (2.6–5.3) | 3.1 (2.1–5.0) | < 0.001 |
| > 35 | 6.1 (3.1–10.0) | 3.0 (2.0–4.8) | < 0.001 |
| Body weight (kg) | |||
| > 50 | 5.3 (2.8–9) | 3.0 (2.0–4.7) | < 0.001 |
| ≤ 50 | 6.1 (3.9–9.9) | 3.0 (2.0–4.3) | < 0.001 |
| Type of tuberculosis | |||
| Extrapulmonary | 6.7 (4.3–9.9) | 3.0 (2.3–4.6) | < 0.001 |
| Smear-positive pulmonary | 6.6 (4.6–10.0) | 3.1 (2.6–4.4) | < 0.001 |
| Smear-negative pulmonary | 5.6 (3.6–9.8) | 4.3 (2.4–5.9) | < 0.001 |
| Enrolled in HIV care before tuberculosis diagnosis | |||
| No | 6.9 (5.1–10.0) | 3.0 (2.2–4.8) | < 0.001 |
| Yes | 5.9 (3.7–10.0) | 3.1 (2.0–5.0) | < 0.001 |
HIV: human immunodeficiency virus; IQR, interquartile range; WHO, World Health Organization.