Timing of antiretroviral therapy in Cambodian hospital after diagnosis of tuberculosis: impact of revised WHO guidelines
Kimcheng Choun, Reaksmey Pe, Sopheak Thai, Natalie Lorent, Lutgarde Lynen & Johan van Griensven
Volume 91, Number 3, March 2013, 195-206
Table 3. Overall probability of initiation of antiretroviral therapy (ART) up to week 8 after the diagnosis of tuberculosis, pre- and post-implementation of the 2010 WHO ART guidelines, by CD4+ cell count and competing risk assumption, Cambodia, December 2008 to November 2011
| CD4+ cell count (cells/µL) | Probability of ART initiation, % (95% CI) |
||
|---|---|---|---|
| At 2 weeks | At 4 weeks | At 8 weeks | |
| Pre-ART death as competing risk | |||
| Pre-implementation | |||
| Overall | 0.8 (0.1–2.7) | 19.5 (14.8–24.8) | 58.0 (51.4–64.1) |
| > 50 | 0.8 (0.1–3.9) | 11.9 (7.1–18.3) | 53.4 (44.2–61.7) |
| ≤ 50 | 1.0 (0.1–5.0) | 29.2 (20.5–38.5) | 64.2 (53.7–72.9) |
| Post-implementation | |||
| Overall | 3.9 (1.7–7.5) | 51.8 (44.2–58.9) | 78.8 (72.0–84.2) |
| > 50 | 0.0 (0–2.8) | 45.8 (34.6–56.4) | 79.0 (68.1–86.6) |
| ≤ 50 |
7.6 (3.3–14.2) |
60.9 (50.0–70.1) |
84.6 (75.3–90.7) |
| Pre-ART death and loss to follow-up as competing risks | |||
| Pre-implementation | |||
| Overall | 0.8 (0.1–2.5) | 17.6 (13.2–22.4) | 51.1 (44.9–57.0) |
| > 50 | 0.8 (0.1–3.8) | 11.5 (6.8–17.7) | 50.1 (41.9–59.0) |
| ≤ 50 | 0.9 (0.1–4.7) | 26.9 (18.8- 35.7) | 58.6 (48.6–67.4) |
| Post-implementation | |||
| Overall | 3.6 (1.6–7.1) | 47.9 (40.6–54.8) | 72.1 (65.1–77.9) |
| > 50 | 0.0 (0–4.4) | 43.9 (33.0–54.2) | 74.4 (63.5–82.5) |
| ≤ 50 | 7.4 (3.3–13.9) | 58.5 (47.9–67.7) | 80.8 (71.3–87.5) |
CI, confidence interval; WHO, World Health Organization.