Bulletin of the World Health Organization

Use of data from registered clinical trials to identify gaps in health research and development

Roderik F Viergever, Robert F Terry & Ghassan Karam

Volume 91, Number 6, June 2013, 416-425C

Table 1. Baseline information on a 5% sample of trials from the International Clinical Trials Registry Platform, 2012

Category No. (%) of selected trials (n = 2381)
Registry name
CT.gov 1316 (55.3)
EU-CTR 540 (22.7)
JPRN 208 (8.7)
ANZCTR 95 (4.0)
ISRCTN 61 (2.6)
ChiCTR 43 (1.8)
CTRI 36 (1.5)
NTR 31 (1.3)
IRCT 23 (1.0)
DRKS 16 (0.7)
CRiS 9 (0.4)
ReBec 2 (0.1)
PACTR 1 (0.0)
RPCEC 0 (0)
SLCTR 0 (0)
Intervention typea
Drugs and biologicals 1562 (65.6)
Surgery and other proceduresb 281 (11.8)
Behaviouralc 168 (7.1)
Device 167 (7.0)
Diagnostic 119 (5.0)
Dietary supplements and diets 106 (4.5)
Physical therapy 64 (2.7)
Radiation 48 (2.0)
Organizational 42 (1.8)
Other 35 (1.5)
Year of registration
Before 2005 26 (1.1)
2005 127 (5.3)
2006 106 (4.5)
2007 158 (6.6)
2008 245 (10.3)
2009 351 (14.7)
2010 462 (19.4)
2011 544 (22.8)
2012 362 (15.2)
Primary sponsor
University or hospital 1459 (61.3)
Industry 495 (20.8)
Collaborative group of doctors or researchers 112 (4.7)
Government institution 99 (4.2)
Individual 97 (4.1)
Research institute 51 (2.1)
Foundation 40 (1.7)
Contract research organization 4 (0.2)
Other 2 (0.1)
Not specified or not classifiable 22 (0.9)
Target number of participants
1–99 1184 (49.7)
100–999 832 (34.9)
≥ 1000 94 (3.9)
Not specified 271 (11.4)
Study phase(s)
0 11 (0.5)
I 166 (7.0)
I/II 86 (3.6)
II 432 (18.1)
II/III 44 (1.8)
III 265 (11.1)
III/IV 1 (0.0)
IV 230 (9.7)
Not specified 1146 (48.2)
Sex of participants
Both 2028 (85.2)
Female 257 (10.8)
Male 96 (4.0)
Age of participantsa
0–27 days 76 (3.2)
28 days–2 years 111 (4.7)
2–11 years 200 (8.4)
< 12 years 247 (10.4)
12–17 years 280 (11.8)
< 18 years 372 (15.6)
18–64 years 2034 (85.4)
≥  65 years 1582 (66.4)
Not specified 127 (5.3)

ANZCTR, Australian New Zealand Clinical Trials Registry; ChiCTR, Chinese Clinical Trial Register; CRiS, Clinical Research Information Service of the Republic of Korea; CT.gov, ClinicalTrials.gov; CTRI, Clinical Trials Registry – India; DRKS, German Clinical Trials Register; EU-CTR, EU Clinical Trials Register; IRCT, Iranian Registry of Clinical Trials; ISRCTN, International Standard Randomized Controlled Trial Number Register; JPRN, Japan Primary Registries Network; NTR, Netherlands National Trial Register; PACTR, Pan African Clinical Trial Registry; ReBec, Brazilian Clinical Trials Registry; RPCEC, Cuban Public Registry of Clinical Trials; SLCTR, Sri Lanka Clinical Trials Registry.

a As some of the classifications within this category overlap, some trials are included in more than one classification.

b “Other procedures” included acupuncture and cell transplants.

C For example, psychotherapy and lifestyle counselling.