The global burden of congenital toxoplasmosis: a systematic review
Paul R Torgerson & Pierpaolo Mastroiacovo
Volume 91, Number 7, July 2013, 501-508
Table 1. Disease weights for the various syndromes associated with congenital toxoplasmosis, together with the estimated incidence of sequelae
|Syndrome||Disability weight||Incidencea (95% CI)|
|Fetal loss (> 24 weeks gestation)||1||2.4 (2.3–6.3)|
|Neonatal death||1||0.7 (0.4–1.2)|
|Chorioretinitis in first year of life||0.033||13 (12–15)|
|Chorioretinitis later in life||0.033||16 (5–52)|
|Chorioretinitis in first year of life (NA and SA)||0.033||80 (70–90)b|
|Chorioretinitis later in life (NA and SA)||0.033||10 (5–15)b|
|Intracranial calcification||0.01||11 (7.9–12)b|
|CNS abnormalities||0.36||2.9 (1.0–6.0)|
CNS, central nervous system; CI, credible interval; NA, North America; SA, South America.
a Per 100 cases.
b To avoid having the incidence of sequelae being greater than the total incidence, in cases from South America these incidences were applied to the residual incidence once sequelae with higher disability weights had been extracted.
Data were obtained from Kortbeek et al.,10 Havelaar et al.14 and Salomon et al.20