Buruli ulcer

Vaccine

Rationale

Buruli ulcer appears to be a largely toxin-mediated disease, the development of an anti-toxin may be one of the approaches towards vaccine development and could also be therapeutically useful. Another factor which supports the feasibility of developing a subunit vaccine against M. ulcerans is that infection is largely extracellular. Therefore antibodies against mycobacterial cell surface structures may have protective activity.

Recommended studies

  • To develop an anti-toxin for use as a vaccine.
  • To search and evaluate protein-based vaccine candidates.
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