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The revision of the surveillance case definition for variant Creutzfeldt-Jakob Disease (vCJD). Report of a WHO consultation Edinburgh, United Kingdom 17 May 2001

WHO/CDS/CSR/EPH/2001/5

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The Revision of the Surveillance Case Definition for Variant Creutzfeldt-Jakob Disease (vCJD). Report of a WHO consultation Edinburgh, United Kingdom 17 May 2001

Contents

Abbreviations used
Background
The Consultation process
Introduction
Key elements in the diagnosis of vCJD
      I. Suspect vCJD: clinical diagnosis
      II.       Probable vCJD
                     The role of EEG in the diagnosis of vCJD
                     The role of 14-3-3 in the diagnosis of vCJD
                     Number of samples positive 14-3-3 /total samples investigated
                     The role of Magnetic Resonance Imaging (MRI) in the diagnosis of vCJD
                     The role of Tonsil Biopsy and Lymphoreticular Tissues in the diagnosis of vCJD
      III.      Definite vCJD
                     The role of neuropathology in the diagnosis of vCJD
Suggested approaches to post-mortem examination
Western blot analysis of PrP isotype in the diagnosis of vCJD
Handling of instruments used to diagnose vCJD
Annex I -     Case Definition for vCJD
Annex II -    Agenda for the Consultation
Annex III -   List of Scientific Presentations to the Consultation
Annex IV -   Participants
Annex V -    Pathological Characteristic of vCJD (from 1998 WHO Consultation)
Annex VI -   EEG Criteria for sCJD
Annex VII -  List of WHO Reference Centres
Annex VIII- Clinical Features of Variant CJD, Sporadic CJD and Suspect vCJD Cases with   an Alternative Final Diagnosis
Annex IX -   Selected References