Global Alert and Response (GAR)

Production of pilot lots of inactivated influenza vaccines from reassortants derived from avian influenza viruses. Interim biosafety risk assessment.

November 2003

WHO/CDS/CSR/RMD/2003.5


Production of pilot lots of inactivated influenza vaccines from reassortants derived from avian influenza viruses. Interim biosafety risk assessment.

1.Introduction
2.Scope of the risk assessment
3.Virus rescue
4.Pathogenicity testing
5.Vaccine production
6.Hazard identification
7.Assignment of a provisional containment level
8.Nature of the work and review of control measures to safeguard human health
9.Environmental hazards and any additional control measures necessary

References
Annex 1. Testing for attenuation of influenza vaccine strains in mammals
Annex 2. Participating partners

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