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Antimicrobial and support therapy for bacterial meningitis in children. Report of the meeting of 18-20 June 1997, Geneva, Switzerland

WHO/EMC/BAC/98/2

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Antimicrobial and support therapy for bacterial meningitis in children. Report of the meeting of 18-20 June 1997, Geneva, Switzerland

Introduction
  • Purpose of the meeting
  • Bacterial meningitis in developing countries
Antimicrobial therapy
  • Empiric antimicrobial therapy for bacterial meningitis
  • Strategies for countries with penicillin and/or chloramphenicol resistance
  • Prospects for affordability of third generation cephalosporins in developing countries
  • Summary of discussions on antimicrobial therapy
Chloramphenicol - A review of recent pharmacokinetic and efficacy data
  • Pharmacokinetic of chloramphenicol adminstered by IV/oral routes
  • Chloramphenicol use in malnourished children
  • Chloramphenicol use in young infants
  • Clinical efficacy of oily chloramphenicol compared with ceftriaxone in bacterial meningitis
  • Summary of discussions on chloramphenicol
Dexamethasone therapy in meningitis
  • Review of available information
  • Summary of the discussions on dexamethasone therapy
Fluid requirements in meningitis management
  • The basis of fluid restriction and current views
  • Developing country perspective - the Chandigarh studies
  • Summary of discussion of fluid therapy in meningitis
Recommendations
  • Antimicrobial therapy for meningitis
  • Use of chloramphenicol
  • The role of dexamethasone
  • Fluid therapy in meningitis
  • CSF testing for diagnostic and surveillance purposes
  • Recommendations for future research

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