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UPDATED: Fri Jun 21 10:35:11 2002

Dr Gro Harlem Brundtland        
Director-General
World Health Organization

Oslo
19 June 2002

   

"Perinatal Mortality and Morbidity - a Global View"

XVIII European Congress of Perinatal Medicine

Your Majesty,

Chairman,

Colleagues,

Ladies and gentlemen,

It is a great pleasure for me to address you today.

As you all know, the last decade has brought enormous progress of science and technology in improving maternal and newborn health. I am thinking of fields such as treatment of genetic diseases, intra-uterine surgery, and improved knowledge about the human genome. This is the reality most of you work within and you have to grapple with the technical possibilities and the ethical dilemmas this new knowledge presents you with.

But the leap in science and technology in the industrialized world has led to a great gap between the situation facing pregnant women in Europe or North America, and that of women in the developing world. I would like to take this opportunity today to describe this reality.

In Norway, as in most countries in Europe, women can receive the news of a pregnancy confident that it will be a period of attention, support and assistance. They can rest assured that the risk of death or even complications is minimal, and that a solid system of dedicated specialists, technology and resources are ready to take care of almost any eventuality.

Most women take this security for granted. This is good and the way it should be.

But as health workers, we should know that for 90% of the pregnancies and deliveries in our world, the reality is very different. A young women in Ethiopia, for example, goes into the reproductive phase of her life with a one-in-ten chance that she will die as a result of pregnancy or delivery. That is not only shocking - it is totally unacceptable.

Poverty has a woman’s face; of the world's 1.3 billion poorest, only 30% are male. Poor women are often caught in a damaging cycle of malnutrition and disease. This plight stems directly from women's place in the home, and in society: it often also reflects gender bias in health care. We often find poor women at the back of the waiting line.

There were 132 million births in the year 2000, 90% of them took place in developing countries where more than 80% of people live.

Today's mothers were born at the times when fertility rates were high, infant mortality rates were falling and major population efforts and programmes had just started. Thirty years of efforts to increase contraceptive use has resulted in reduced fertility all over the world.

However, we have seen that the main factor affecting fertility is the changing socio-economic conditions that have taken place in these countries over the past three decades. They have reduced the optimal size of a family. They have also led to better education for women, and given women better control of their own reproductive choices. But far from all women have access to contraception. As a result, unsafe abortion rates are high.

We can conclude that access to appropriate and available contraceptives at affordable cost is important for assisting families in obtaining their goal of controlling their fertility. But even more important, this access is important in securing and protecting the health of women.

Statistics of developing countries show that the relevant indicators of pregnancy outcomes are the same as they were in the 1930's in England. The causes of bad outcomes in developing countries are also often similar to those in the era before antibiotics and oxytocins.

European countries, in contrast rank high, on the top of lists of health indicators. But also within post-cold-war Europe we see drastic differences in indicators for pregnancy and childbirth. Some countries show maternal mortality five times as high as others. The perinatal mortality is double in some countries than in others. The poor are hit the most, as in the rest of the world.

The average risk for women in developing countries of dying in childbirth is 1 in 60, but it can go as high as 1 in 10 in the least developed countries. In comparison, in Western Europe, the risk is 1 in 5000.

Maternal, infant and child mortality illustrate the largest gaps between the rich and the poor in today’s world. There are between 7 and 8 million perinatal deaths, but we do not know exactly how many are stillbirths and how many are early neonatal deaths. In many cases, births of infants who die soon after birth are neither recorded nor counted.

This situation is unacceptable. That is why Heads of State of the world, at the Millennium Summit in New York in 2000 made reducing child mortality and improving maternal health as key Millennium Development Goals. By 2015 the target is to reduce by two thirds the under-five mortality ratio and by three quarters the maternal mortality ratio.

We know that there is no need for advanced and expensive technology to achieve these figures. Basic hygiene, access to trained health workers, and simple, well tried technology could ensure that the vast majority of these deaths and complications could be averted.

Mothers need follow up by trained personnel during pregnancy and a delivery supervised by midwives or trained nurses. They need access to emergency services if anything goes wrong. Newborns need a smooth transition into postnatal life, feeding, warmth and hygiene. A small proportion of infants need special care for illness or low birth weight.

Although exact medical causes in countries may differ, the problem is simple: the common denominator for those deaths is the lack of appropriate and quality services, confounded by poverty.

A high proportion of pregnant women do not have access to even the most basic services for pregnancy and childbirth. Differences in services for women in urban and rural areas in each country are also large. The poorest women get the least services.

Despite two Safe Motherhood conferences, and 15 years of recognition of the importance of skilled attendance and other basic recommendations, progress has been painstakingly slow.

The reasons for this are many. One is the special nature of pregnancy and childbirth compared with approaches addressing endemic diseases and nutritional deficiencies: It is labour-intensive in nature. A five-minute consultation is not enough during a delivery. And, when complications occur, there is a need for complex services immediately, around the clock, 7 days a week, 24 hours a day, until mother and baby are safe.

Poverty, distances to health facilities and inadequate transportation are also key reasons. The fact remains that millions of deaths are preventable each year. The knowledge exists and so does the technology.

The historical Scandinavian model of quality midwifery service delivery and governmental support contributed to relatively low rates of maternal and neonatal mortality at the times when today’s technology was not available. Sri Lanka is just one example of a developing country where political commitment and steady investment in pregnancy and childbirth services have resulted in low maternal and perinatal mortality.

We do not have to wait until poverty is drastically reduced before we can get results. What we do see, though, is that maternal and perinatal mortality are a good measure of the performance of health care. In other words, we must see perinatal work as a part of the efforts to scale up investments and reforms of existing health systems in developing countries.

Looking at the daunting challenge in front of us, many are relying on the traditional providers. Traditional providers in this area are a reality of today but it is not a solution for the future.

While their role in providing different kinds of care around the childbirth period should be recognized, there is no evidence that they can manage on their own once complications arise and there is a need for special services. This area requires two kinds of skills: to know the normal and to be patient, but also to recognize the abnormal and to react quickly once complications arise. For this, we need skilled attendants, doctors, midwives and nurses. There is no way around this fact.

One of the major successes of perinatal medicine is prevention, early detection and treatment of malformations and genetic diseases. Statistics of developed countries show that mortality due to malformation has decreased substantially.

The potential health burden of congenital disorders can be greatly reduced by implementing basic reproductive health approaches, including family planning, adequate diet, prevention and management of maternal infections. This is information and services mothers cannot get from traditional providers.

Your Majesty,

There are a number of other issues that are affecting perinatal health.

One such issue is nutrition.

Food insecurity, hunger and malnutrition dominate the health of the world's poorest nations.

Alleviation of hunger and malnutrition is a fundamental pre-requisite for poverty reduction and sustainable development.

More than 570 million of the world's women suffer from anaemia, which contributes to the severity of complications in pregnancy and childbirth. This affects infants too.

We know today that under-nutrition in-utero permanently changes the body's structure, physiology and metabolism and increases the risks of heart disease and stroke in adult life.

The nutrition of the fetus reflects the nutrition of the mother throughout her life, including her own fetal life. It is not simply what happens to her during pregnancy.

Where malnutrition is prevalent, more efforts should go towards improving nutrition of the whole family.

Birth weight is a crude summary of fetal experience.

WHO and UNICEF estimate that 15% of babies weigh less than 2500g at birth. In some countries, a full one third of all babies born are below this weight. Yet, probably only 1/3 of infants are weighed at birth and it is among those births without weight statistics we are likely to find the poorest .

We know what low-birth-weight means for immediate survival. We are only starting to understand the importance of long-term effects of fetal under-nutrition, but we are concerned that it could be a drawback that will be carried forward through several generations. It is a vicious cycle.

Industrialized countries and the countries in transition are facing the other side - obesity associated with complications of pregnancy. This is a growing problem. We know even less about the long-term/ life effects on the fetus of obesity than we know about under-nutrition.

We need to learn more about cost-effective interventions for both worlds: How do we best protect mother and child from malnutrition? We do not have the answers.

But we have some successes we can build on. Iodine is one such example. Iodine deficiency is the main single cause of preventable brain damage in childhood.

But by adding iodine to salt, we have a safe, cheap and sustainable way of eliminating the problem. Since 1992, remarkable progress has been made in providing iodized salt to affected populations. Iodized salt now reaches nearly 70% of the households in affected countries.

WHO, together with a number of private and public sector collaborators, are also working to add other important micro-nutrients to basic food like flour, rice, and sugar. This will not solve the problem of malnutrition, but it may alleviate it while we struggle to eliminate the main cause of the problem, abject poverty.

Proper perinatal care also includes attacking the diseases which threaten the health of mother and baby.

In large parts of Africa and some areas of Asia, malaria is a major cause of anaemia. In some areas, women can suffer four or five serious bouts of malaria every year. In addition to causing anaemia, the disease increases risks to the fetus. In addition, malaria is the largest killer of children in Africa. Together, malaria and AIDS are responsible for one third of all deaths of children below five years of age.

More and more young girls are getting infected with HIV and becoming mothers before reaching biological and social maturation. The results are tragic: they are transmitting infection to their children, they are dying early because of obstetrical complications or AIDS, and they are leaving young orphans behind.

The figures are staggering: The majority of those who are newly infected with HIV are aged less than 24 and most of these are girls. Their infection rates are increasing. As I have been speaking this afternoon, 85 young people were infected with HIV: that's five a minute.

The vast majority of this catastrophe is playing out in Africa. But we have seen a terrible increase in infection rates in Russia and several of the countries of the former Soviet Union. And infection rates are steady or even slightly increasing in the rest of Europe. There is no room for complacency.

There are urgent tasks to stem the tide.

The first is prevention. We know it works. Thailand, Uganda, Senegal and Cambodia have shown us that. But it only works when the commitment comes from the president or prime minister. The whole country must be able to speak openly about the danger, the causes and the solution.

It includes finding and making available effective methods for dual protection - from HIV and other sexually transmitted infections and from unwanted pregnancy.

Prevention of mother-to-child transmission requires improving services and interventions with respect to access to and cost of drugs. We are making progress in this direction, rolling out a programme for access everywhere by HIV-infected women to nevirapine.

Your Majesty,

Over the past decade, we have seen tremendous progress in cloning cells, treating diseases before and after birth, as well as treating a range of maternal and neonatal complications and diseases. This progress is promising further reduction of the already low infant mortality in industrialized countries.

Meanwhile, developing countries are facing the major challenge of making the best use of limited resources to improve the health of women and children.

Lately, we have seen disturbing signs of what we can only call "fashions" of interventions sweeping over several developing countries which not only do not represent the best use of these limited resources, but also could be dangerous.

There is an ongoing "epidemic" of cesarean sections in Asia and Latin America. This worldwide fad of obstetrical interventions may have a serious negative health impact on women. In contrast, the low rates observed in Africa reflect a lack of resources more than a consensus of providers.

The commercial and litigation pressures that drive this "epidemic", need to be countered. Professionals in industrial countries have an important role to play. You could build stronger strategies to promote evidence-based interventions and develop strategies to prevent or reverse harmful practices.

We do not yet know the dimensions and effects of sex selective practices. It has been estimated that world-wide between 60 and 100 million girls are missing. This demographic inequality is a result of different practices, ranging from sex-selective abortion to often fatal neglect of the health and nutritional needs of girls.

This is not only unethical and a breach of basic human rights, but is also leading to serious social and health problems for societies. We must assist our colleagues in such countries so that they do not become unwitting or coerced accomplices to such practices.

Goals have been set and commitments made at the population Summit in Cairo, at the women's summit in Beijing, at the social summit in Copenhagen and as I mentioned at the Millennium Summit in New York.

Yet, progress is painfully slow. How can we help this change?

Two and a half years ago, I asked leading economists and health experts from around the world, to come together in a Commission on Macroeconomics and Health. I asked them to focus on the complex set of relationships that exist between health, economic development, and poverty reduction.

For too many years, investments in health were seen by many economists as an add-on which developing countries could only afford after having reached a higher income level. I was convinced this was wrong: you need a two-pillar approach. A healthy population is a prerequisite for growth as much as a result of it.

Six months ago, the Commission delivered its report. It was a clear and strong argument for how increased investment in health is a prerequisite for social and economic development in the poorest countries in the world.

According to the report, pregnancy and childbirth services are among the essential services of the minimal health system of every country.

These essential services need to be based on public funding, but the poorest countries lack financial resources to meet even the most basic needs of their populations. The report therefore calls for a dramatic scaling up of resources for health. Although most of this increase should come from reprioritizing of the developing countries' own resources, half of the total amount - or $27 billion per year - will have to come from increased development assistance from rich countries.

Already, countries have begun to respond. We have seen small, but significant increases in aid budgets of several rich nations, including the United States. Even more important, a large part of this increase is earmarked for health.

WHO is working to make sure maternal and perinatal care is part of the essential health package that will result from this scale-up for health.

Your Majesty,

Colleagues,

For most of you here today, the work-day is far removed from the issues confronting poor women in Cambodia or Cameroon. But there are ways in which your actions can help these women in the long run.

One is research. The development of research partnerships between developing and industrialized countries will not only help to combat the global inequity of health but will also be of enormous mutual benefit for all.

Another is spreading knowledge, through articles, through personal contact, through dialogue with other countries' health professionals and governments. Pregnancy, childbirth and being a newborn are not diseases - they are special periods in human life when the risk of death or disability can be very high. This must be understood clearly by all: from medical, nursing and midwifery schools, from research funding bodies to industry and governments. Not understanding or knowing well the normal can lead to abuse of technology and iatrogenic complications.

It is vitally important for developing countries to maintain a focus on the basics of what can and should be done in this important field of public health. It amounts to the development of more functional health care systems for all. Developing countries look to industrial ones for new developments and best practices. Your actions at home will also influence world-wide trends.

As you spend the next two days discussing the important issues on your agenda, I know you will keep in mind the global perspective. The scope of improvements is impressive. And the results are invaluable. It can be counted in lives saved. Millions of women and infants who instead of facing death can hope for a healthy life.

Thank you.

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