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Drug resistance

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Antimicrobial Resistance

Antimicrobial agents are considered "miracle drugs" that are our leading weapons in the treatment of infectious diseases. Antimicrobial resistance is the ability of certain microorganisms to withstand attack by antimicrobials, and the uncontrolled rise in resistant pathogens threatens lives and wastes limited healthcare resources.

Microbes and Antimicrobial Agents

Antimicrobial agents are medicines used to treat infections caused by bacteria, fungi, parasites, and viruses. The discovery of antimicrobials is one of the most important advances in health in human history - decreasing suffering from disease and saving lives.

:: Discovery and development

The rise in resistant microorganisms

The use and misuse of antimicrobials in human medicine and animal husbandry over the past 70 years has led to a relentless rise in the number and types of microorganisms resistant to these medicines - leading to death, increased suffering and disability, and higher healthcare costs.

:: Emergence and spread
:: Public health importance
:: Surveillance of antimicrobial resistance

What can be done?

Two factors drive the rise and spread of resistant microbes: 1. Overuse and misuse of antimicrobials and 2. the spread of resistant organisms between individuals, communities, and countries.

Combatting antimicrobial resistance thus requires interventions in two areas:

:: Improving antimicrobial use
:: Blocking transmission of resistant organisms

     

Containment of Antimicrobial Resistance

Urgent and coordinated action is required at local, national, and international levels to ensure the adequate treatment of patients today and the preservation of the life-saving power of antimicrobials for future generations.

:: What WHO is doing
:: WHO Global Strategy for Containment of Antimicrobial Resistance
:: Global Patient Safety Challenge: Tackling Antimicrobial Resistance

WHO PROGRAMMES AND RESOURCES IN ANTIMICROBIAL RESISTANCE

:: Child and Adolescent Health
:: Food Safety and Zoonoses
:: Global Malaria Programme
:: HIV/AIDS Department
:: Infection Control
:: Patient Safety
:: Reproductive Health
:: Stop TB Department
DOCUMENTS AND PUBLICATIONS

- Antimicrobial Resistance Document Centre
- Frequently Asked Questions
- Fact Sheet (2002)

ANTIMICROBIAL RESISTANCE OUTSIDE OF WHO HEADQUARTERS

:: WHO Regional Offices
:: WHO Collaborating Centres
:: Other Organizations and Links


HIGHLIGHTS

WHO Global Strategy for Containment of Antimicrobial Resistance
Full text

Manual for the laboratory identification and antimicrobial susceptibility testing of bacterial pathogens of public health concern in the developing world
Full text

Surveillance of antimicrobial resistance
WHONET Software

Surveillance of antimicrobial use
Guidelines and ABC Calc

Information for specific pathogens and diseases
Document Centre for resources on specific organisms and disease issues

Manual for the laboratory identification and antimicrobial susceptibility testing of bacterial pathogens of public health concern in the developing world
Full text


ANTIMICROBIAL RESISTANCE OUTSIDE OF WHO HEADQUARTERS

WHO Regional Offices
WHO Collaborating Centres
Other organizations and partners