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Laboratory Diagnosis of Sexually Transmitted Diseases
E. Van Dyck, Z.A. Meheus and P. Piot
1999, xi + 135 pages (available in English; French and Spanish in preparation)
ISBN 92 4 154501 1
Sw.fr. 35./US $31.50; in developing countries: Sw.fr. 24.50
Order no. 1150434
This manual provides an authoritative guide to standard laboratory procedures for detecting and diagnosing sexually transmitted diseases. Addressed to clinical microbiologists and medical technologists, the manual is designed to serve as a practical bench aid, tuned to the needs and capacities of laboratories at different levels in the health system. Although the standard procedures described have universal relevance, particular attention is given to conditions in developing countries, where rapid transport of specimens may not be possible and cost factors may be decisive. Recommended procedures, tests, and techniques are supported by close to 150 references.
Noting the constraints on staff and resources faced by most laboratories throughout the world, the manual concentrates on tests known to yield essential diagnostic information. Standard antimicrobial susceptibility tests are described for those diseases where drug resistance is a problem. Although the major emphasis is on procedures for diagnosis, case-finding, and test-of-cure, some procedures useful in epidemiological research are also included.
The manual has nine chapter covering the full range of sexually transmitted diseases: gonorrhoea, Chlamydia trachomatis infection, syphilis, genital herpes, chancroid, granuloma inguinale, vaginitis in adults, human papillomavirus infection, and human immunodeficiency virus. Each chapter opens with a brief description of the disease and the principal laboratory approaches to diagnosis, followed by detailed advice on the collection and transport of specimens. Against this background, all relevant laboratory methods, from microscopy, culture and non-culture techniques to serology and the use of commercial test kits, are described in detail, with colour plates used to illustrate selected procedures and results.
Apart from providing detailed step-by-step instructions for each procedure, the manual offers abundant practical advice on the selection of tests, their comparative sensitivity and specificity, the degree of skill required, the correct interpretation of results, and common errors and how to avoid them. The chapter on HIV infection reproduces the latest joint UNAIDS and WHO recommendations for the selection and use of HIV antibody tests.
Further practical guidance for each of these diseases is provided in three annexes, which summarize appropriate diagnostic tests at different levels of the laboratory system, describe the media, reagents, and stains required for the tests, and list all the basic products needed to prepare essential reagents and media.
Management of Patients with Sexually Transmitted Diseases
Report of a WHO Study Group
Technical Report Series, No. 810
1991, vii + 103 pages [C, E, F, R, S]
ISBN 92 4 120810 4
Sw.fr. 14.-/US $12.60; in developing countries: Sw.fr. 9.80
Order no. 1100810
Sets out practical measures for dealing with the growing public health problems caused by sexually transmitted diseases, including HIV infection. Addressed to the clinicians and auxiliary health workers who diagnose and treat patients, the book concentrates on the many things that can be done, even under highly imperfect conditions, to help realize the twin goals of reducing transmission and preventing morbidity. While stressing the advantages gained when services are integrated with primary care or with programmes for the prevention of HIV infection and AIDS, the book also alerts its readers to the many obstacles to be overcome in countries where funds and facilities are limited, where patients often seek treatment outside the health services, and where many low-cost treatments have been rendered useless by the spread of drug resistance.
The main part presents model management protocols for each
of 15 clinical syndromes and problems commonly seen at the primary health care level.
These syndrome-based protocols are intended to help the non-specialist clinician make a
diagnosis and initiate treatment based on the epidemiological, clinical and therapeutic
information available. Each protocol, which is presented in the form of a flow-chart, is
accompanied by a brief definition of the syndrome, a note about its importance, and a
description of etiological features, followed by a summary of the clinical observations
and laboratory findings that should guide management plans.