Daily iron supplementation in children 6-23 months of age
It is estimated that worldwide, 600 million preschool and school-age children are anaemic, and it is assumed that at least half of these cases are attributable to iron deficiency. Children are particularly vulnerable to iron deficiency anaemia because of their increased iron requirements in the periods of rapid growth, especially in the first five years of life. Iron deficiency anaemia in children has been linked to increased childhood morbidity and impaired cognitive development and school performance.
Iron supplementation has proven to be effective in increasing haemoglobin concentrations in children, especially in those who are anaemic.
WHO recommendations
Daily iron supplementation is recommended as a public health intervention in infants and young children aged 6–23 months, living in settings where the prevalence of anaemia is 40% or higher in this age group*, for preventing iron deficiency and anaemia.
* In the absence of prevalence data in this group, consider proxies for high risk of anaemia. For the most recent estimates, visit the WHO-hosted Vitamin and Mineral Nutrition Information System (VMNIS).
Additional information for this recommendation, including a suggested scheme for supplementation, can be found in the guidance summary and in the guideline, under 'WHO documents' below.
WHO documents
GRC-approved guidelines
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Daily iron supplementation in infants and children
Publication date: 2016
Other guidance documents
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Iron deficiency anaemia: assessment, prevention and control - A guide for programme managers
Publication date: 2001
Evidence
Systematic reviews used to develop the guidelines
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Effect of daily iron supplementation on health in children aged 4–23 months: a systematic review and meta-analysis of randomised controlled trials
Pasricha SR, Hayes E, Kalumba K, Biggs BA.
Lancet Glob Health. 2013;1(2):e77-86. -
Oral iron supplements for children in malaria-endemic areas
Neuberger A, Okebe J, Yahav D, Paul M.
Cochrane Database of Systematic Reviews. 2016; Issue 2. Art. No.: CD006589. - Summary of this review
Other related systematic reviews
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Effect of iron supplementation on haemoglobin response in children: systematic review of randomised controlled trials
Gera T, Sachdev HPS, Nestel P, Sachdev SS.
Journal of Pediatric Gastroenterology & Nutrition. 2007; 44:468–486.