e-Library of Evidence for Nutrition Actions (eLENA)

Macronutrient supplementation in people living with HIV/AIDS

Weight loss and undernutrition are common in people living with HIV/AIDS and are likely to accelerate disease progression, increase morbidity and reduce survival. Nutritional interventions such as macronutrient supplementation may help meeting additional energy needs and improve the nutritional status of undernourished people living with HIV/AIDS, leading to improved clinical outcomes and therefore improved quality of life and survival.

The current, limited evidence base suggests that while macronutrient supplementation may increase energy intake, no conclusions can be drawn about the effects of macronutrient supplementation on reducing disease progression or HIV-related complications, such as opportunistic infections or death. Further research is required to fully assess the impact of macronutrient supplementation on the health of people living with HIV/AIDS.

Adequate nutrition, which is best achieved through consumption of a balanced healthy diet, is vital for health and survival for all individuals regardless of HIV status.

WHO recommendations

Further research is needed before specific recommendations can be made.

WHO documents

WHO documents

GRC-approved guidelines

Status: not currently available

Other guidance documents


Related Cochrane reviews
Clinical trials

Last update:

15 June 2017 14:52 CEST

Category 2 intervention

Systematic review(s) have been conducted but no recent guidelines yet available that have been approved by the WHO Guidelines Review Committee

Biological, behavioural and contextual rationale