eLENA interventions and global targets
Evidence linking intermittent iron for non-anaemic pregnant women to global targets*
Global nutrition targets 2025
40% reduction in the number of children under-5 who are stunted
Direct evidence for a link between intermittent iron supplementation in non-anaemic pregnant women and reduced risk of stunting is not currently available at the systematic review level. Results of a 2015 systematic review and meta-analysis found that intermittent iron and folic acid supplementation during pregnancy was associated with reduced risk of low birth weight. Results of a 2013 pooling analysis of longitudinal birth cohorts found that low birth weight was associated with increased odds of both stunting and wasting in childhood, providing indirect evidence for a link between intermittent iron supplementation in non-anaemic pregnant women and reduced odds of stunting.
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Intermittent oral iron supplementation during pregnancy
Peña-Rosas JP, De-Regil LM, Gomez Malave H, Flores-Urrutia MC, Dowswell T.
Cochrane Database of Systematic Reviews 2015, Issue 10. Art. No.: CD009997. -
Risk of childhood undernutrition related to small-for-gestational age and preterm birth in low- and middle-income countries
Christian P, Lee SE, Donahue Angel M, Adair LS, Arifeen SE, Ashorn P, et al.
Int J Epidemiol. 2013; 42(5):1340-55.
50% reduction of anaemia in women of reproductive age
Direct evidence for the effect of intermittent iron and folic acid supplementation in non-anaemic pregnant women on anaemia in women of reproductive age comes from results of a 2015 systematic review and meta-analysis which found that intermittent iron and folic acid supplementation in non-anaemic pregnant women was associated with reduced risk of anaemia during pregnancy.
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Intermittent oral iron supplementation during pregnancy
Peña-Rosas JP, De-Regil LM, Gomez Malave H, Flores-Urrutia MC, Dowswell T.
Cochrane Database of Systematic Reviews 2015, Issue 10. Art. No.: CD009997.
30% reduction in low birth weight
Direct evidence for the effect of intermittent iron and folic acid supplementation in non-anaemic pregnant women on low birth weight comes from results of a 2015 systematic review and meta-analysis which found that intermittent iron and folic acid supplementation in non-anaemic pregnant women was associated with reduced risk of low birth weight.
-
Intermittent oral iron supplementation during pregnancy
Peña-Rosas JP, De-Regil LM, Gomez Malave H, Flores-Urrutia MC, Dowswell T.
Cochrane Database of Systematic Reviews 2015, Issue 10. Art. No.: CD009997.
Reduce and maintain childhood wasting to less than 5%
Direct evidence for a link between intermittent iron supplementation in non-anaemic pregnant women and reduced risk of wasting is not currently available at the systematic review level. Results of a 2015 systematic review and meta-analysis found that intermittent iron and folic acid supplementation during pregnancy was associated with reduced risk of low birth weight. Results of a 2013 pooling analysis of longitudinal birth cohorts found that low birth weight was associated with increased odds of both stunting and wasting in childhood, providing indirect evidence for a link between intermittent iron supplementation in non-anaemic pregnant women and reduced wasting.
-
Intermittent oral iron supplementation during pregnancy
Peña-Rosas JP, De-Regil LM, Gomez Malave H, Flores-Urrutia MC, Dowswell T.
Cochrane Database of Systematic Reviews 2015, Issue 10. Art. No.: CD009997. -
Risk of childhood undernutrition related to small-for-gestational age and preterm birth in low- and middle-income countries
Christian P, Lee SE, Donahue Angel M, Adair LS, Arifeen SE, Ashorn P, et al.
Int J Epidemiol. 2013; 42(5):1340-55.
* With few exceptions, links noted between interventions and global nutrition or NCD targets are based on published evidence resulting from systematic reviews of the literature. Individual studies were not assessed unless they were included in such a published review.
Coloured icons indicate that there is evidence of a direct link between the intervention of interest and target(s); i.e. systematic reviews are available assessing the effect of the intervention on an outcome directly relevant to the targets (e.g. prevalence of stunting, rate of breastfeeding, etc.).
Grey icons indicate that there is evidence of an indirect link between the intervention of interest and target(s). Where indirect links have been noted, systematic reviews linking the intervention directly to one or more targets are not currently available; i.e. the studies included in the review(s) do not assess the effect of the intervention on the outcomes that are directly relevant to the targets. For example, systematic reviews directly linking breastfeeding to stunting are not currently available. However, systematic reviews linking breastfeeding to a reduction in diarrhoea are available, as are reviews linking diarrhoea to increases in stunting. Therefore, interventions that increase breastfeeding rates may indirectly reduce stunting. Additionally, indirect links may be noted when the only available outcome data is for an indicator used to assess outcomes relevant to the targets. For example, body mass index (BMI) is an indicator for overweight and obesity and an intervention that reduces BMI may contribute to decreasing rates of overweight and/or obesity. Therefore, an indirect link would be noted between interventions for which systematic review(s) report BMI as an outcome, and the global overweight and obesity targets.