Vitamin D supplementation and respiratory infections in children
Vitamin D is known to play an important role in bone metabolism through regulation of calcium and phosphate homeostasis and may also play an important role in immune system regulation. Vitamin D is produced by the body during exposure to sunlight, but is also found in oily fish, eggs and fortified food products.
In addition to causing rickets, vitamin D deficiency has been linked to respiratory infections such as pneumonia, tuberculosis and bronchiolitis. Pneumonia is a severe form of acute lower respiratory tract infection and is the leading cause of death in children worldwide.
Some studies have suggested that vitamin D supplementation can decrease the frequency and severity of respiratory infections among children, however further research is needed before specific recommendations can be made.
WHO recommendations
Further research is needed before specific recommendations can be made.
WHO documents
GRC-approved guidelines
Status: not currently available
Evidence
Related Cochrane reviews
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Vitamin D supplementation for preventing infections in children under five years of age
Yakoob MY, Salam RA, Khan FR, Bhutta ZA.
Cochrane Database of Systematic Reviews. 2016; Issue 11. Art. No.: CD008824.
Other related systematic reviews
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Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data
Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P et al.
BMJ. 2017;356:i6583. -
Vitamin D and Respiratory Tract Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Bergman P, Lindh AU, Björkhem-Bergman L, Lindh JD.
PLoS One. 2013; 8:e65835. -
Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis
Charan J, Goyal JP, Saxena D, Yadav P.
Journal of Pharmacology and Pharmacotherapeutics. 2012; 3:300-3.