Vitamin D supplementation during pregnancy
Vitamin D is known to play an important role in bone metabolism through regulation of calcium and phosphate homeostasis. Vitamin D is produced by the body during exposure to sunlight, but is also found in oily fish, eggs and fortified food products. Deficiency is thought to be common among pregnant women in some populations, and has been found to be associated with an increased risk of pre-eclampsia, gestational diabetes mellitus, preterm birth, and other tissue-specific conditions.
Vitamin D supplementation during pregnancy improves maternal vitamin D status and may positively affect the availability of vitamin D to the fetus. However, due to the limited evidence currently available to directly assess the benefits and harms of the use of vitamin D supplementation alone in pregnancy for improving maternal and infant health outcomes, WHO does not recommend the use of this intervention during pregnancy as part of routine antenatal care.
Systematic reviews used to develop the guidelines
Other related systematic reviews
Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis