Zinc supplementation and growth in children
Approximately 155 million children under five years of age are stunted (height-for-age < -2 SD below the WHO Child Growth Standards median), with the vast majority living in Africa and Asia.
Zinc is important for cellular growth, cellular differentiation and metabolism and deficiency limits childhood growth and decreases resistance to infections. Although severe zinc deficiency is rare in humans, mild to moderate deficiency may be common worldwide.
The available evidence is inconsistent, but suggests that zinc supplementation may help to improve linear growth of children under 5 years of age.
WHO recommendations
Further research is needed before specific recommendations can be made.
WHO documents
GRC-approved guidelines
Status: not currently available
Evidence
Related Cochrane reviews
-
Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years of age
Mayo-Wilson E, Junior JA, Imdad A, Dean S, Chan XHS, Chan ES, et al.
Cochrane Database of Systematic Reviews. 2014; Issue 5. Art. No.: CD009384. - Summary of this review
Other related systematic reviews
-
Effect of preventive zinc supplementation on linear growth in children under 5 years of age in developing countries: a meta-analysis of studies for input to the lives saved tool
Imdad A, Bhutta ZA.
BMC Public Health. 2011; 11(Suppl. 3):S22. -
Effects of micronutrients on growth of children under 5 y of age: meta-analyses of single and multiple nutrient interventions
Ramakrishnan U, Nguyen P, Martorell R.
American Journal of Clinical Nutrition. 2009; 89(1):191–203. -
Preventive zinc supplementation among infants, preschoolers, and older prepubertal children
Brown KH, Peerson JM, Baker SK, Hess SY.
Food & Nutrition Bulletin. 2009; 30(Suppl. 1):S12-40.
