Human Genetics programme

Typical Orofacial Clefts- cumulative data by Register

Updated: January 2007


Register Period Sent Births Cleft Lip Cleft Lip/Palate Cleft Palate Pierre Robin Total Cases % CL+CLP Total Rate 95% CI Total rate*10,000
South Africa SABDSS 2001-2002-2003 69,321 4 16 10 3 33 60.6 4.76 3.28 6.69
Spain-Basque Countries 2001-2002-2003 55,188 9 20 9 5 43 67.4 7.79 5.64 10.50
Italy-BDRCAM 2001-2002-2003 172,300 32 47 55 8 142 55.6 8.24 6.94 9.71
USA-Tennessee* 2000-2001 157,857 41 39 52 0 132 60.6 8.36 7.00 9.92
USA-West Virginia 2000-2001-2002-2003-2004 101,654 17 34 29 2 98 52.0 9.64 7.83 11.75
Southern Portugal 2001-2002 37,163 6 18 9 3 36 66.7 9.69 6.79 13.41
Italy-IMER 2001-2002-2003 81,642 12 36 25 7 80 60.0 9.80 7.77 12.20
Croatia 2001-2002-2003 16,739 4 7 6 0 17 64.7 10.16 5.92 16.26
Uruguay 2001-2002-2003 24,591 7 12 5 1 25 76.0 10.17 6.58 15.01
Israel IBDMS 2002-2003-2004 26,317 13 6 7 1 27 70.4 10.26 6.76 14.93
USA-Illinois 2000-2001 369,025 65 166 143 8 382 60.5 10.35 9.34 11.44
Italy-Tuscany 2001-2002-2003 80,505 16 32 33 3 84 57.1 10.43 8.32 12.92
Italy-North East 2002-2003-2004 169,601 68 37 67 6 178 59.0 10.50 9.01 12.16
USA-Rhode Island 2000-2001-2002-2003 49,451 13 27 11 1 52 76.9 10.52 7.85 13.79
France-Central East 2001-2002-2003-2004-2005 531,630 109 220 176 69 574 57.3 10.80 9.93 11.72
United Arab Emirates 2002-2003 17,188 6 6 5 2 19 63.2 11.05 6.66 17.26
Malta 2001-2002-2003 11,629 6 2 3 2 13 61.5 11.18 5.95 19.12
Spain-Asturias 2001-2002-2003 20,911 5 9 8 2 24 58.3 11.48 7.36 17.08
Russia Moscow Region 2002-2003-2004 161,595 40 76 75 10 201 57.7 12.44 10.78 14.28
UK-North Thames 2001-2002-2003 140,672 43 83 50 6 182 69.2 12.74 10.67 15.10
Canada-British Columbia 2001-2002-2003-2004 162,030 59 85 59 4 207 69.6 12.78 11.09 14.64
Hungary 2001-2002-2003-2004 385,714 110 197 162 28 497 61.8 12.89 11.78 14.07
Ukraine 2001-2002-2003-2004 101,510 43 44 40 6 133 65.4 13.10 10.97 15.53
Venezuela 2001-2002-2003 70,485 21 59 10 3 93 86.0 13.19 10.65 16.16
USA-Hawaii 2000-2001-2002-2003-2004-2005 106,637 32 55 42 12 141 61.7 13.22 11.13 15.59
Austria-Styria 2001 10,050 2 9 2 1 14 78.6 13.93 7.62 23.37
Belgium-Hainaut 2001-2002-2003 36,461 14 15 21 1 51 56.9 13.99 10.42 18.39
Italy-ISMAC 2001-2002 33,022 7 18 19 3 47 53.2 14.23 10.46 18.93
USA-Atlanta 2001-2002-2003-2004 205,882 62 128 79 38 307 61.9 14.91 13.29 16.68
UK-Wessex 2001-2002-2003 77,785 34 36 42 5 117 59.8 15.04 12.44 18.03
Czech Republic 2001-2002-2003-2004 375,947 137 200 228 12 577 58.4 15.35 14.12 16.65
Poland** 2001-2002-2003 724,742 229 412 457 20 1,118 57.3 15.43 14.54 16.36
USA-Arkansas 2001-2002 74,423 21 64 25 8 118 72.0 15.86 13.12 18.99
USA-Colorado 2000-2001 132,434 47 98 64 2 211 68.7 15.93 13.86 18.23
Slovak Republic 2001-2002-2003-2004-2005 258,112 75 186 143 11 415 62.9 16.08 14.57 17.70
Colombia 2001-2002-2003 21,014 4 18 12 0 34 64.7 16.18 11.21 22.61
UK-Oxford 2001-2002-2003 18,334 4 11 14 1 30 50.0 16.36 11.04 23.36
Chile 2001-2002-2003 150,608 35 123 79 10 247 64.0 16.40 14.42 18.58
France-Paris 2002-2003 77,000 25 58 29 17 129 64.3 16.75 13.99 19.91
USA-Kentucky 2000-2001-2002 164,946 49 113 94 23 279 58.1 16.91 14.99 19.02
USA-Michigan 2001-2002-2003 393,615 63 377 190 36 666 66.1 16.92 15.66 18.26
Ireland-Dublin 2001-2002-2003 68,469 24 32 46 15 117 47.9 17.09 14.13 20.48
Switzerland - Vaud 2001-2002-2003 20,942 9 13 10 4 36 61.1 17.19 12.04 23.80
Belgium-Antwerp 2001-2002-2003 52,868 24 38 25 7 94 66.0 17.78 14.37 21.76
Mexico RYVEMCE 2002-2003-2004 79,537 25 94 22 2 143 83.2 17.98 15.15 21.18
UK-Wales 2000-2001-2002-2003-2004-2005 189,161 65 113 137 28 343 51.9 18.13 16.26 20.16
Argentina 2001-2002-2003 183,272 58 200 53 23 334 77.2 18.22 16.32 20.29
USA-Alabama 2000-2001-2002-2003-2004 83,779 31 59 45 18 153 58.8 18.26 15.48 21.40
France-Strasbourg 2001 13,860 8 6 7 5 26 53.8 18.76 12.26 27.50
Ecuador 2001-2002-2003 43,492 10 56 11 5 82 80.5 18.85 15.00 23.40
Australia VBDR 2001-2002-2003-2004 251,312 92 151 160 74 477 50.9 18.98 17.32 20.76
Brasile 2001-2002-2003 120,509 49 116 58 10 233 70.8 19.34 16.93 21.98
USA-Oklahoma 2000-2001-2002-2003 200,925 79 192 100 30 401 67.6 19.96 18.05 22.01
Canada-Alberta 2002-2003-2004 118,952 53 92 55 38 238 60.9 20.00 17.55 22.72
Northern Netherlands 2001-2002-2003 60,924 35 54 30 11 130 68.5 21.34 17.83 25.34
USA-Utah 2000-2001-2002-2003-2004 245,138 145 198 130 56 529 64.8 21.58 19.78 23.50
Germany-Saxony Anhalt 2001-2002-2003-2004-2005 87,458 31 123 32 15 201 76.6 22.98 19.92 26.39
Denmark-Odense 2001-2002-2003 15,768 10 16 9 2 37 70.3 23.47 16.53 32.34
Japan JAOG 2001-2002-2003-2004 347,889 230 467 103 21 821 84.9 23.60 22.01 25.27
Bolivia 2001-2002-2003 20,215 12 31 5 0 48 89.6 23.75 17.51 31.48
Finland 2004 57,945 21 33 63 23 140 38.6 24.16 20.33 28.51
Paraguay 2001-2002-2003 11,111 6 16 3 2 27 81.5 24.30 16.02 35.36
Germany-Mainz 2001-2002-2003 9,443 5 12 10 0 27 63.0 28.59 18.85 41.60
TOTAL 8,158,699 2,611 5,311 3,703 769 12,410 63.8 15.21 14.94 15.48

* provisional data
** includes Wielkopolska registry

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