Genomic resource centre

Mediterranean Europe

Isolated Cases

Updated: January 2007

Mediterranean Europe: Number of total cases, percentage of cases and 95% Conf. Interval

	Cleft Lip	Cleft Lip+ Palate	All CleftLip +/- Cleft Palate	Cleft Palate	Pierre Robin	All Cleft Palate	Total
No.	147	144	291	177	33	210	501
%	50.5	49.5	58.1	84.3	15.7	41.9	100.0
CI 95%	44.6-56.4	43.6-55.4	53.6-62.4	78.6-88.9	11.1-21.3	37.5-46.4

Mediterranean Europe: Rates*10,000 and 95% Conf. Interval

	Cleft Lip	Cleft Lip+ Palate	All CleftLip +/- Cleft Palate	Cleft Palate	Pierre Robin	All Cleft Palate	Total
No.	147	144	291	177	33	210	501
Rate (*10,000)	2.1	2.1	4.2	2.6	0.5	3.1	7.3
CI 95%	1.8-2.5	1.8-2.5	3.8-4.7	2.2-3	0.3-0.7	2.6-3.5	6.6-7.9

Mediterranean Europe: Proportion of Termination of Pregnancy (TOP)

	Cleft Lip	Cleft Lip+ Palate	All CleftLip +/- Cleft Palate	Cleft Palate	Pierre Robin	All Cleft Palate	Total
No.	139	140	279	170	30	200	479
No. TOP	3	7	10	0	0	0	10
%	2.2	5.0	3.6	0.0	0.0	0.0	2.1
CI 95%	0.4-6.2	39123.0	1.7-6.3	0-2.1	0-11.6	0-1.8	1-3.8

Mediterranean Europe: Sex ratio (LB+SB) and 95% Conf. Interval

	Cleft Lip	Cleft Lip+ Palate	All CleftLip +/- Cleft Palate	Cleft Palate	Pierre Robin	All Cleft Palate	Total
No.	141	134	275	171	32	203	478
M/M+F	0.60	0.67	0.63	0.51	0.59	0.53	0.59
CI 95%	0.51-0.68	0.58-0.75	0.57-0.69	0.44-0.59	0.41-0.76	0.46-0.6	0.54-0.63

Mediterranean Europe: Sex ratio (TOP) and 95% Conf. Interval

	Cleft Lip	Cleft Lip+ Palate	All CleftLip +/- Cleft Palate	Cleft Palate	Pierre Robin	All Cleft Palate	Total
No.	2	7	9	0	0	0	9
M/M+F	1.00	0.71	0.78	nc	nc	nc	0.78
CI 95%	0.16-1	0.29-0.96	0.4-0.98	nc	nc	nc	0.4-0.97

Mediterranean Europe: Median and interquartile range for birth weight (LB+SB)

	Cleft Lip	Cleft Lip+ Palate	All CleftLip +/- Cleft Palate	Cleft Palate	Pierre Robin	All Cleft Palate	Total
No.	125	126	251	164	31	195	446
Median	3250	3162.5	3200	3230	3220	3230	3220
IQ Range	2830-3620	2750-3500	2780-3550	2810-3600	2776-3650	2800-3600	2800-3580

Mediterranean Europe: Proportion of LB+SB under 2.500 grams

	Cleft Lip	Cleft Lip+ Palate	All CleftLip +/- Cleft Palate	Cleft Palate	Pierre Robin	All Cleft Palate	Total
No.	125	126	251	164	31	195	446
No. under 2.500grams	7	23	30	19	3	22	52
%	5.6	18.3	12.0	11.6	9.7	11.3	11.7
CI 95%	2.3-11.2	11.9-26.1	8.2-16.6	7.1-17.5	0.2-25.7	7.2-16.6	8.8-15.8

Mediterranean Europe: Median and interquartile range for gestational age (LB+SB)

	Cleft Lip	Cleft Lip+ Palate	All CleftLip +/- Cleft Palate	Cleft Palate	Pierre Robin	All Cleft Palate	Total
No.	124	122	246	160	30	190	436
Median	39	39	39	39	39	39	39
IQ Range	38-40	38-40	38-40	38-40	38-40	38-40	38-40

Mediterranean Europe: Proportion of LB+SB under 37 weeks of gestage

	Cleft Lip	Cleft Lip+ Palate	All CleftLip +/- Cleft Palate	Cleft Palate	Pierre Robin	All Cleft Palate	Total
No.	124	122	246	160	30	190	436
No. under 37 weeks	14	14	28	14	3	17	45
%	11.3	11.5	11.4	8.8	10.0	8.9	10.3
CI 95%	6.3-18.2	6.4-18.5	7.7-16	4.9-14.2	0.2-26.5	5.3-13.9	7.6-13.6

Mediterranean Europe: Proportion of LB+SB with SGA

	Cleft Lip	Cleft Lip+ Palate	All CleftLip +/- Cleft Palate	Cleft Palate	Pierre Robin	All Cleft Palate	Total
No.	113	118	231	157	30	187	418
No. with SGA	22	27	49	33	6	39	88
%	19.5	22.9	21.2	21.0	20.0	20.9	21.1
CI 95%	12.6-28	15.6-31.5	16.1-27	14.9-28.2	7.7-38.6	15.3-27.4	17.2-25.3

Mediterranean Europe: Rate of twin deliveries=twins deliveries/twin deliveries+singleton deliveries

	Cleft Lip	Cleft Lip+ Palate	All CleftLip +/- Cleft Palate	Cleft Palate	Pierre Robin	All Cleft Palate	Total
No.	140	141	281	166	32	198	479
No. twin deliveries	2	7	9	2	0	2	11
%	1.4	5.0	3.2	1.2	0.0	1.0	2.3
CI 95%	0.2-5.1	39123.0	1.5-6	0.1-4.3	0-10.9	0.1-3.6	1.1-4.1

nc= not calculable

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