Human Genomics in Global Health

Immunization Against Alzheimer's Disease and Other Neurodegenerative Disorders

By D.J Selkoe and Y. Christen

ISSN: 0945-6066

Price: EURO 74.95

Series: Research and Perspectives in Alzheimer’s Disease

Publisher: Springer-Verlag, Heildelberg

About the book
The promising effects of beta-amyloid immunization in mice, reported in a recent study, stimulated substantial research and raised high hopes in the field. In retrospect, this study seems both logical, being consistent with that amyloid theory central to the study of Alzheimer’s disease today, and paradoxical, because it used the toxic substance itself for a treatment benefit. The ensuing research opened up multiple perspectives for experimentation and treatment but clinical trials that were subsequently started had to be discontinued in January 2002 due to the serious side effects of the therapy. The aim of this book is not to arouse false hopes for a therapeutic project that remains to be proven, but to discuss the available information and the questions raised.