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Asthma

• More information on genetics and common diseases

• Polymorphism of angiotensin-converting enzyme gene and genetic susceptibility to asthma with familial aggregation
  Gao J, Lin Y, Xiao Y, Xu K, Xu W, Zhu Y, Ma Y, Bai Y.
  Chinese Medical Sciences Journal 2000 Mar;15(1):24-8.
• Genomic Approaches to Understanding Asthma
  Lyle J. Palmerand William O.C.M. Cookson
  Genome Research 2000 Sept, Vol. 10, Issue 9, 1280-1287
• Interleukin-12: potential role in asthma therapy
  Leonard P, Sur S.
  BioDrugs 2003;17(1):1-7.
• Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies
  Lazarus R, Klimecki WT, Raby BA, Vercelli D, Palmer LJ, Kwiatkowski DJ, Silverman EK, Martinez F, Weiss ST.
  Genomics 2003 Jan;81(1):85-91
• Treatment of experimental asthma by long-term gene therapy directed against IL-4 and IL-13.
  Zavorotinskaya T, Tomkinson A, Murphy JE.
  Molecular Therapy 2003 Feb;7(2):155-62.
• Genetic linkage analysis of a dichotomous trait incorporating a tightly linked quantitative trait in affected sib pairs.
  Huang J, Jiang Y.
  American Journal of Human Genetics 2003 Apr;72(4):949-60. Epub 2003 Mar 17
• Association between HLA-DQA1, -DQB1 gene polymorphisms and susceptibility to asthma in northern Chinese subjects.
  Gao J, Lin Y, Qiu C, Liu Y, Ma Y, Liu Y.
  Chinese Medical Journal (Engl) 2003 Jul;116(7):1078-82.
• Indication of linkage and genetic heterogeneity for asthma and atopy on chromosomes 8p and 12q in 107 French EGEA families.
  Dizier MH, Quesneville H, Besse-Schmittler C, Guilloud-Bataille M, Selinger-Leneman H, Clerget-Darpoux F, Demenais F.
  European Journal of Human Genetics 2003 Aug;11(8):590-6.
• Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes.
  Raby BA, Silverman EK, Lazarus R, Lange C, Kwiatkowski DJ, Weiss ST.
  Human Molecular Genetics 2003 Aug 15;12(16):1973-9
• Asthma Genetics 2003
  Scott T. Weiss and Benjamin A. Raby
  Human Molecular Genetics; 2004; Vol. 13 Review Issue 1
• Toll-like receptor 4 polymorphism and severity of atopy in asthmatics
  Yang IA, Barton SJ, Rorke S, Cakebread JA, Keith TP, Clough JB, Holgate ST, Holloway JW
  Genes and Immunity2004 Jan;5(1):41-5.
• Genetics, epigenetics, and the environment: switching, buffering, releasing.
  Vercelli D.
  The Journal of Allergy and Clinical Immunology 2004 Mar;113(3):381-6; quiz 387.
• Characterization of a common susceptibility locus for asthma-related traits.
  Laitinen T, Polvi A, Rydman P, Vendelin J, Pulkkinen V, Salmikangas P, Makela S, Rehn M, Pirskanen A, Rautanen A, Zucchelli M, Gullsten H, Leino M, Alenius H, Petays T, Haahtela T, Laitinen A, Laprise C, Hudson TJ, Laitinen LA, Kere J.
  Science 2004 Apr 9;304(5668):300-4.
• Genetics of asthma and COPD. Similar results for different phenotypes.
  Meyers DA, Larj MJ, Lange L.
  Chest 2004 Aug;126(2 Suppl):105S-110S; discussion 159S-161S