7.2.5 T B co-treatment in children with HIV
Consolidated ARV guidelines, June 2013
TB is one of the most common opportunistic infections affecting children with HIV. Selecting regimens that are compatible with TB therapy is therefore essential. Interactions between rifampicin and LPV/r or NVP mean that co-treatment in children under three years is challenging, but a recent large randomized controlled trial (163) of ART in children has generated preliminary evidence on the efficacy of triple nucleoside therapy which, despite limited data in the context of TB co-treatment, offers a suitable option for children who require TB treatment while already receiving ART (Table 7.12).
The recommended regimens for children diagnosed with TB and starting ART are consistent with the 2010 recommendations and are summarized in Table 7.12, together with broader guidance on choosing regimens for co-treatment of HIV and TB.