7.4 Monitoring and substitutions for ARV drug toxicities
Consolidated ARV guidelines, June 2013
7.4.2 Major types of ARV toxicities
The 2010 WHO ART guidelines recommended a symptom-directed approach to laboratory monitoring of the safety and toxicity of ART regimens. At the same time, several laboratory tests for monitoring ARV toxicity were advised (but not required) for specific high-risk people using certain drugs. Table 7.15 lists key types of toxicity and associated risk factors for the major ARV drugs.
Monitoring drug toxicity using a symptom-directed approach needs to be investigated further to optimize treatment. More data are needed on whether routine or periodic laboratory monitoring for specific types of toxicity (such as renal function monitoring among TDF users) is required for all individuals or only people at higher risk.