7.5.1 Second-line ART for adults and adolescents
Consolidated ARV guidelines, June 2013
The 2010 WHO ART guidelines recommended that second-line adult regimens include a boosted-PI plus two NRTIs (determined by the drug used in first-line therapy). Those guidelines placed a high value on using simpler second-line regimens, ideally heat-stable formulations and fixed-dose combinations (once-daily formulations when possible).
Except for the recommendation for people with HIV and TB, the recommendations in 2013 remain unchanged from the 2010 recommendations.