7.1.4 When to start ART in children
Consolidated ARV guidelines, June 2013
Key research gaps
More data are needed to define potential clinical benefits and the impact of initiating ART early on morbidity for children younger than five years as well as immunological response and virological response over time.
The impact of initiating ART earlier on retention, adherence and potential HIV drug resistance among children with less advanced disease needs to be investigated further. Data are also needed to inform the optimal approach to initiating ART in children coinfected with HBV.