5.2 HIV prevention based on ARV drugs
Consolidated ARV guidelines, June 2013
5.2.3 Post-exposure prophylaxis for occupational and non-occupational exposure to HIV
Post-exposure prophylaxis is short-term ART to reduce the likelihood of acquiring HIV infection after potential exposure either occupationally or through sexual intercourse. Within the health sector, post-exposure prophylaxis should be provided as part of a comprehensive package of universal precautions that reduces the exposure of personnel to infectious hazards at work. WHO post-exposure prophylaxis guidelines for occupational exposure have not been reviewed since 2006 and will be updated by 2014.
The current recommended duration of post-exposure prophylaxis for HIV infection is 28 days, and the first dose should be offered as soon as possible within 72 hours after exposure. The choice of post-exposure prophylaxis drugs should be based on the country’s first-line ART regimen for HIV. A recent recommendation (39) relates specifically to post-exposure prophylaxis in the case of sexual assault.
Existing recommendation (2013) (39)
Consider HIV post-exposure prophylaxis for women presenting within 72 hours of a sexual assault. Use shared decision-making with the survivor to determine whether HIV post-exposure prophylaxis is appropriate (strong recommendation, very-low-quality evidence).
Source for recommendation
Responding to intimate partner violence and sexual violence against women: clinical and policy guidelines. Geneva, World Health Organization, in press (39).