Guidelines on co-trimoxazole prophylaxis for HIV-related infections among children, adolescents and adults

Recommendations for a public health approach

In high-income countries, co-trimoxazole prophylaxis among children (both those exposed to HIV and those living with HIV) and adults and adolescents living with HIV has been the standard of care for many years. WHO and UNAIDS have not produced guidelines for national programmes in resource-limited settings. In the absence of clear guidelines, countries and programmes have been slow in adopting co-trimoxazole prophylaxis, a lifesaving, simple and inexpensive intervention. The objective of these guidelines is to provide global technical and operational recommendations for the use of co-trimoxazole prophylaxis in HIV-exposed children, children living with HIV and adolescents and adults living with HIV in the context of scaling up HIV care in resource-limited settings.