The evolving role of CD4 cell counts in HIV care

Journal article in Current Opinion in HIV & AIDS

Nathan Ford, Graeme Meintjes, Marco Vitoria, Greg Greene, and Tom Chiller

Publication details

Number of pages: 6
Publication date: March 2017
ISBN: DOI:10.1097


Purpose of review

The role of the CD4 cell count in the management of people living with HIV is once again changing, most notably with a shift away from using CD4 assays to decide when to start antiretroviral therapy (ART). This article reflects on the past, current and future role of CD4 cell count testing in HIV programmes, and the implications for clinicians, programme managers and diagnostics manufacturers.


As countries revise guidelines to provide ART to all people living with HIV and continue to scale up access to viral load, strategic choices will need to be made regarding future investments in CD4 cell count and the appropriate use for clinical disease management.

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