Applying Precaution in the context of chemical safety
Hazard and risk assessment tools
High Production Volume Information System
The High Production Volume Information System (HPVIS) provides complete and easy access to technical health and environmental effect information on chemicals that are manufactured in exceptionally large amounts. Information in this database are submitted through EPA's High Production Volume (HPV) Challenge Program. HPVIS allows users to search for summary information, test plans, and new data on high production volume chemicals as they are developed.
EPA has developed an evaluation tool, the PBT Profiler, which predicts PBT potential of chemicals. The PBT Profiler estimates environmental persistence (P), bioconcentration potential (B), and aquatic toxicity (T) of discrete chemicals based on their molecular structure. It is Internet-based and there is no cost for use. The user enters a chemical using the Chemical Abstract Service Registry Number (CASRN). If the chemical is in the accompanying database of more than 100,000 chemicals, the structure is retrieved and entered into the model. A drawing program is also available so that the user can draw and enter the structure or the structure can be entered as a line notation using the Simplified Molecular Input Line Entry System (SMILES). The PBT Profiler is a web-based evaluation tool that may be valuable for those developing new chemicals or considering the use of new chemicals.
ECOSAR (Ecological Structure Activity Relationships) is a personal computer software program that is used to estimate the toxicity of chemicals used in industry and discharged into water. The program predicts the toxicity of industrial chemicals to aquatic organisms such as fish, invertebrates, and algae by using Structure Activity Relationships (SARs). The program estimates a chemical's acute (short-term) toxicity and, when available, chronic (long-term or delayed) toxicity.
OncoLogic is a desktop computer program that evaluates the likelihood that a chemical may cause cancer.
Netherlands Ministry of Housing, Spatial Planning and Environment Quick Scan Process
Netherlands Ministry of Housing, Spatial Planning and Environment Quick Scan Process. The Quick Scan Process is a rapid qualitative risk assessment and prioritization process for chemicals in commerce. It provides a simple way to categorize and prioritize chemicals based on a minimal data set.
The Danish EPA
The Danish EPA has developed an advisory list for self-classification of dangerous substances including 20,624 substances. The substances have been identified by means of computer models, so-called QSAR models (Quantitative Structure-Activity Relationship)
Developed by the UK Health and Safety Executive, COSHH Essentials provides advice on controlling the use of chemicals for a range of common tasks, eg mixing, or drying.