Immunization, Vaccines and Biologicals

Correlates of vaccine-induced protection: methods and implications

Publication details

Number of pages: 65
Publication date: 3 June 2013
WHO reference number: WHO/IVB/13.01


The document presents an overview of definitions and methods in the area of immune correlates of vaccine-induced protection. This subject has far-reaching implications for the evaluation of vaccine efficacy, for passive protection, e.g. maternal immunity and risk screening, e.g. tuberculin testing or rubella antibody testing of pregnant women, as well as for basic understanding of pathogenesis and immunity.